Center for Interdisziplinary Research

Towards Molecular Systems Biology

Date: June 6 - 9, 2006
Organizers: Norbert Sewald, Dario Anselmetti, Wolf-Jürgen Beyn, Karsten Niehaus, Alfred Pühler, Jens Stoye (all Bielefeld)

In Molecular Systems Biology the quantitative understanding of complex and controlled biological processes at the cellular level requires a deep insight into the relationships of the overall functional information of the diverse genetically programmed and dynamically regulated networks. Scientists from molecular biology, mathematics, bioinformatics, chemistry and physics will have to combine their research expertise to work on this long-term objective of quantitative real-time description of all relevant, non-linear and dynamic cell networks. Besides the integral analysis of an entire cell at all different levels of organisation (genome, transcriptome, proteome, metabolome) the ultimate goal is the generation of computational cell models that can predict the effect of a pertubation to a cell, its dysfunction and the origin and fundamentals of biological adaptability and the 'robustness of life'.

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