Aziz-Lange, Ghadwal, Glaser, Godt, Hellweg, Hoge, Kohse-Höinghaus, Kühnle, Mitzel
Life Science Chemistry
Dierks, Fischer v. Mollard, Gröger, Hellweg, Kottke, Lübke, Niemann, Sewald
Gas Phase- und Atmospheric Chemistry
Brockhinke, Eisfeld, Kohse-Höinghaus, Koop, Manthe, Mitzel
Public Understanding of Science
Dunker, Kohse-Höinghaus, Lück, Mitzel
Important subjects in the research area Molecule-based Materials are molecular magnets, biomimetic catalysts, cytostatic compounds, fluorinated compounds, organometallic compounds, silanes, spin probes an models for EPR-spectroscopy, microgels and microemulsions.
Protein crystallography is used and sulfatases, lysosomal hydrolases and membrane transport are studied in the research area Life Science Chemistry. An additional focus are bioorganic and biocatalytic topics in organic chemistry groups, which are also investigated by biochemistry groups within the Faculty of Chemistry.
Research topics in Gas Phase- und Atmospheric Chemistry are combustion, atmospheric aerosols and ice nucleation. The core facility „gas-electron diffraction and structure analysis of small molecules“ (GED@BI, N. Mitzel) is funded by the DFG and is unique within the EU.
The research area Public Understanding of Science focuses on research concerning instructions in chemistry during early childhood.
The Faculty of Chemistry is characterized by interdisciplinary research, which is typical for Bielefeld University. Researchers in the research area Molecule-based Materials cooperate with the department of Physics.
The research area Life Science Chemistry is strengthened by cooperation with the Faculty of Biology, the Faculty of Technology and the CeBiTec.
The „Center for Molecular Materials“ CM2 is an academic department with groups from chemistry and physics (coordinator B.Hoge), which aims at connections between technical know-how of industrial partners and basic research at the university.
In addition, each group is involved in national and international research cooperations.
Three-Fold Scholl-Type Cycloheptatriene Ring Formation around a Tribenzotriquinacene Core: Toward Warped Graphenes
An unprecedented 3-fold Scholl-type cycloheptatriene ring formation around a tribenzotriquinacene core is realized, producing a polyaromatic arene with a wizard hat-shaped structure. The presence of three 3,4-dimethoxyphenyl rings at the C-1, C-4 and C-8 positions of the tribenzotriquinacene skeleton is crucial to the success of this transformation.
H.-W. Ip, C.-F. Ng, H.-F. Chow and D. Kuck, J. Am. Chem. Soc. 2016, 138, 13778–13781. [DOI: 10.1021/jacs.6b05820]
Investigating RET RTK Signaling Pathways Using an IAP–Based Activity–Profiling Approach
Many neurodegenerative diseases, such as Parkinson′s disease, can be directly correlated with the deregulation in neuronal signaling. Hence, it is indispensable for therapy development to understand the participating signaling processes. Because the activity of the involved protein kinases is of major interest for the investigation of these signaling processes, an affinity–based chemical proteomics approach that allows for the activity profiling of protein kinases was developed within this study. This approach was applied to investigate the RET9 receptor tyrosine kinase signaling pathway that plays a central role in neuronal signaling. In addition to already known RET9 downstream targets, several other protein kinases were found to be highly activated upon RET9 stimulation.
Michael Höfener, Fiona Pachl, Tim Take, Gabriele Fischer von Mollard, Bernhard Kuster,
Norbert Sewald, J. Proteome Res.2014, 13, 3628–3634.