Fakultät für Chemie - Strukturbiochemie
 
 
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Universität Bielefeld > Department of Chemistry > Research Groups > Structural Biochemistry

Publications of Prof. Dr. Hartmut Niemann


Peer Reviewed Original Research


Harwardt MIE, Young P, Bleymüller WM, Meyer T, Karathanasis C, Niemann HH, Heilemann M, Dietz MS. (2017)

Membrane dynamics of resting and internalin B-bound MET receptor tyrosine kinase studied by single-molecule tracking.

FEBS Open Bio. 7, 1422-1440

 

Bleymüller WM, Lämmermann, N, Ebbes M, Maynard D, Geerds C, Niemann HH (2016)

MET-activating Residues in the B-repeat of the Listeria monocytogenes Invasion Protein InlB.

J. Biol. Chem. 291, 25567-25577

 

Schreiner M, Schlesinger R, Heberle J, Niemann HH (2016)

Crystal structure of Halobacterium salinarum halorhodopsin with a partially depopulated primary chloride-binding site

Acta Crystallogr F Struct Biol Commun, F72, 692-699

PDF Reprint

 

Koschut D, Richert L, Pace G, Niemann HH, Mély Y, Orian-Rousseau V (2016)

Live cell imaging shows hepatocyte growth factor-induced Met dimerization.

Biochim Biophys Acta.1863, 1552-1558

 

Volz Y, Koschut D, Matzke-Ogi A, Dietz MS, Karathanasis C, Richert L, Wagner MG, Mely Y, Heilemann M, Niemann HH, Orian-Rousseau V (2015)

Direct Binding of Hepatocyte Growth Factor and Vascular Endothelial Growth Factor to CD44v6

Biosci. Rep.35, e00236

 

Barden S, Niemann HH (2015)

Adhesion of Several Cell Lines to Helicobacter pylori CagL is Mediated by Integrin αVβ6 via an RGDLXXL Motif

J. Mol. Biol. 427, 1304-1315

 

Geerds C, Wohlmann J, Haas A, Niemann HH (2014)

Structure of Rhodococcus equi virulence-associated protein B (VapB) reveals an eight-stranded antiparallel β-barrel consisting of two Greek-key motifs.

Acta Crystallogr. F Struct. Biol. Commun. 70, 866-871

 

Barden S, Schomburg B, Conradi J, Backert S, Sewald N, Niemann HH (2014)

Structure of a three-dimensional domain-swapped dimer of the Helicobacter pylori type IV secretion system pilus protein CagL.

Acta Crystallogr. D Biol. Crystallogr. 70, 1391-1400

PDF Reprint

 

Breitsprecher D, Gherardi E, Bleymüller WM, Niemann HH (2014)

Crystal structure of an engineered YopM-InlB hybrid protein.

BMC Struct. Biol. 14:12

 

Kolditz F, Krausze J, Heinz DW, Niemann HH, Müller-Goymann C (2014)

Wound Healing Potential of a Dimeric InlB Variant Analyzed by In Vitro Experiments on Re-epithelialization of Human Skin Models.

Eur. J. Pharm. Biopharm.86, 277-283

 

Dietz MS, Fricke F, Krüger C, Niemann HH, Heilemann M (2014)

Receptor-Ligand Interactions: Binding Affinities Studied by Single-Molecule and Super-Resolution Microscopy on Intact Cells.

Chemphyschem 15, 671-676

 

Barden S, Lange S, Tegtmeyer N, Conradi J, Sewald N, Backert S, Niemann HH (2013)

A Helical RGD Motif Promoting Cell Adhesion: Crystal Structures of the Helicobacter pylori Type IV Secretion System Pilus Protein CagL.

Structure 21, 1931-1941

 

Dietz MS, Haße D, Ferraris DM, Göhler A, Niemann HH, Heilemann M (2013)

Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells.

BMC Biophys. 6:6

Comment on this article in BMC Biophysics

Editorial Highlight in Biome

 

Niemann HH, Gherardi E, Bleymüller WM, Heinz DW (2012)

Engineered variants of InlB with an additional leucine-rich repeat discriminate between physiologically relevant and packing contacts in crystal structures of the InlB:MET complex

Protein Sci. 21, 1528-1539

Editorial Highlight in Protein Science

 

Schreiner M, Niemann HH (2012)

Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycD in complex with a peptide of the minor translocator YopD

BMC Struct. Biol. 12:13

 

Thoms S, Hofhuis J, Thöing C, Gärtner J, Niemann HH (2011)

The unusual extended C-terminal helix of the peroxisomal α/ϐ-hydrolase Lpx1 is involved in dimer contacts but dispensable for dimerization

J. Struct. Biol. 175, 362-371

 

Ebbes M, Bleymüller WM, Cernescu M, Nölker R, Brutschy B, Niemann HH (2011)

Fold and function of the InlB B-repeat.

J. Biol. Chem. 286, 15496-15506

 

Lutz J, Brabeck C, Niemann HH, Kloz U, Korth C, Lingappa VR, Bürkle A (2010)

Microdeletions within the hydrophobic core region of cellular prion protein alter its topology and metabolism

Biochem. Biophys. Res. Commun. 393, 439-444

 

Ferraris DM, Gherardi E, Di Y, Heinz DW, Niemann HH (2010)

Ligand-Mediated Dimerization of the Met Receptor Tyrosine Kinase by the Bacterial Invasion Protein InlB

J. Mol. Biol. 395, 522-532

Cover of Journal of Molecular Biology in January 2010

Postprint in the HZI Repositorium

 

Jung C, Matzke A, Niemann HH, Schwerk C, Tenenbaum T, Orian-Rousseau V (2009)

Involvement of CD44v6 in InlB-dependent Listeria invasion

Mol. Microbiol. 72, 1196-1207

 

Niemann HH, Petoukhov MV, Härtlein M, Moulin M, Gherardi E, Timmins P, Heinz DW, Svergun D (2008)

X-ray and neutron small-angle scattering analysis of the complex formed by the Met receptor and the Listeria monocytogenes invasion protein InlB

J. Mol. Biol. 377, 489-500

Postprint in the HZI Repositorium

 

Büttner CR, Sorg I, Cornelis GR, Heinz DW, Niemann HH (2008)

Structure of the Yersinia enterocolitica Type III Secretion Translocator Chaperone SycD

J. Mol. Biol. 375, 997-1012

PDF Postprint in the HZI Repositorium


Bosse T, Ehinger J, Czuchra A, Benesch S, Steffen A, Wu X, Schloen K, Niemann HH, Scita G, Stradal TE, Brakebusch C, Rottner K (2007)

Cdc42 and Phosphoinositide 3-Kinase Drive Rac-Mediated Actin Polymerization Downstream of c-Met in Distinct and Common Pathways

Mol. Cell. Biol. 27, 6615-6628

PDF Postprint in the HZI Repositorium


Niemann HH, Jäger V, Butler PJG, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW (2007)

Structure of the human receptor tyrosine kinase Met in complex with the Listeria invasion protein InlB

Cell 130, 235-246

PDF Postprint in the HZI Repositorium

Comments on this article in Cell, in Nature Reviews in Microbiology and Faculty of 1000


Baumann F, Tolnay M, Brabeck C, Pahnke J, Kloz U, Niemann HH, Heikenwälder M, Rulicke T, Bürkle A, Aguzzi A (2007)

Lethal recessive myelin toxicity of prion protein lacking its central domain

EMBO J. 26, 538-547


Niemann HH, Schmoldt HU, Wentzel A, Kolmar H, Heinz DW (2006)

Barnase fusion as a tool to determine the crystal structure of the small disulfide-rich protein McoEeTI

J. Mol. Biol. 356, 1-8

 

Büttner, CR, Cornelis GR, Heinz, DW, Niemann HH (2005)

Crystal structure of Yersinia enterocolitica type III secretion chaperone SycT

Protein Sci. 14, 1993-2002

Cover of Protein Science in August 2005

 

Machner MP, Frese S, Schubert WD, Orian-Rousseau V, Gherardi E, Wehland J, Niemann HH,  Heinz DW (2003)

Aromatic amino acids at the surface of InlB are essential for host cell invasion by Listeria monocytogenes

Mol. Microbiol. 48, 1525-1536


Klockow B, Tichelaar W, Madden DR, Niemann HH, Akiba T, Hirose K, Manstein DJ (2002)

The dynamin A ring complex: molecular organization and nucleotide-dependent conformational changes

EMBO J. 21, 240-250


Niemann HH, Knetsch MLW, Scherer A, Manstein DJ, Kull FJ (2001)

Crystal structure of a dynamin GTPase domain in both nucleotide-free and GDP-bound forms

EMBO J. 20, 5813-5821


Dietzel S, Niemann H, Brückner B, Maurange C, Paro R (1999)

The nuclear distribution of Polycomb during Drosophila melanogaster development shown with a GFP fusion protein

Chromosoma 108, 83-94


Ramirez-Alvarado M, Blanco FJ, Niemann H, Serrano L (1997)

Role of β-turn residues in β-hairpin formation and stability in designed peptides

J. Mol. Biol. 273, 898-912


Maercker C, Harjes P, Neben M, Niemann H, Sianidis G, Lipps HJ (1997)

The formation of new nucleoli during macronuclear development of the hypotrichous ciliate Stylonychia lemnae visualized by in situ hybridization

Chromosome Res. 5, 333-335



Reviews


Niemann HH (2013)

Structural basis of MET receptor dimerization by the bacterial invasion protein InlB and the HGF/SF splice variant NK1

Biochim. Biophys. Acta 1834, 2195-2204

Cover of BBA Proteins and Proteomics in October 2013

 

Niemann HH (2011)

Structural insights into Met receptor activation

Eur. J. Cell Biol. 90, 972-981

 

Niemann HH, Schubert WD, Heinz DW (2004)

Adhesins and invasins of pathogenic bacteria: a structural view

Microbes Infect. 6, 101-112

 

 

Other Publications (not peer reviewed)


Niemann HH, Jäger V, Butler PJG, van den Heuvel J, Schmidt S, Ferraris D, Gherardi E, Heinz DW (2007)
A bacterial key to host cell entry: Activation of the human receptor tyrosine kinase Met by a bacterial ligand
ESRF Highlights 2007, 60-61


Büttner CR, Cornelis GR, Heinz DW, Niemann HH (2005)
Crystal structure of Yersinia enterocolitica type III secretion chaperone SycT
BESSY Annual Report 2005, 417-418


Niemann H (2003)
Structural Characterization of dynamin GTPases
B.I.F. Futura 18, 208-212


Dietzel S, Niemann H, Paro R (1999)

Visualization of the development of Drosophila embryos with a polycomb-GFP fusionprotein

Movies on the CD-ROM "GFP in Motion", compiled by Ludin B, Matus A, Trends in Cell Biology 9

Movies in Quicktime format are available on the homepage of Steffen Dietzel.