Aziz-Lange, Ghadwal, Glaser, Godt, Hellweg, Hoge, Kohse-Höinghaus, Kühnle, Mitzel
Life Science Chemistry
Dierks, Fischer v. Mollard, Gröger, Hellweg, Kottke, Lübke, Niemann, Sewald
Gas Phase- und Atmospheric Chemistry
Brockhinke, Eisfeld, Kohse-Höinghaus, Koop, Manthe, Mitzel
Public Understanding of Science
Dunker, Kohse-Höinghaus, Lück, Mitzel
Important subjects in the research area Molecule-based Materials are molecular magnets, biomimetic catalysts, cytostatic compounds, fluorinated compounds, organometallic compounds, silanes, spin probes an models for EPR-spectroscopy, microgels and microemulsions.
Protein crystallography is used and sulfatases, lysosomal hydrolases and membrane transport are studied in the research area Life Science Chemistry. An additional focus are bioorganic and biocatalytic topics in organic chemistry groups, which are also investigated by biochemistry groups within the Faculty of Chemistry.
Research topics in Gas Phase- und Atmospheric Chemistry are combustion, atmospheric aerosols and ice nucleation. The core facility „gas-electron diffraction and structure analysis of small molecules“ (GED@BI, N. Mitzel) is funded by the DFG and is unique within the EU.
The research area Public Understanding of Science focuses on research concerning instructions in chemistry during early childhood.
The Faculty of Chemistry is characterized by interdisciplinary research, which is typical for Bielefeld University. Researchers in the research area Molecule-based Materials cooperate with the department of Physics.
The research area Life Science Chemistry is strengthened by cooperation with the Faculty of Biology, the Faculty of Technology and the CeBiTec.
The „Center for Molecular Materials“ CM2 is an academic department with groups from chemistry and physics (coordinator B.Hoge), which aims at connections between technical know-how of industrial partners and basic research at the university.
In addition, each group is involved in national and international research cooperations.
Three-Fold Scholl-Type Cycloheptatriene Ring Formation around a Tribenzotriquinacene Core: Toward Warped Graphenes
An unprecedented 3-fold Scholl-type cycloheptatriene ring formation around a tribenzotriquinacene core is realized, producing a polyaromatic arene with a wizard hat-shaped structure. The presence of three 3,4-dimethoxyphenyl rings at the C-1, C-4 and C-8 positions of the tribenzotriquinacene skeleton is crucial to the success of this transformation.
H.-W. Ip, C.-F. Ng, H.-F. Chow and D. Kuck, J. Am. Chem. Soc. 2016, 138, 13778–13781. [DOI: 10.1021/jacs.6b05820]
Scientists from Bielefeld and Siegen University have developed a photochromic compound whose activity to intercalate into dsDNA (double-straind DNA) can be controlled by light. Intercalators and especially switchable ones are of high interest for controlling biochemical recognition processes. Potential applications are tremendous and research activity is strongly increasing in many laboratories around the world.
Beside a recognition part the key of these compounds consists of a photochromic unit (photoswitch) whose structure and electronic behaviour can be reversibly changed by light exposure. In this joint contribution an N-methylphenanthrolinium-annelated spirooxazine derivative was prepared. Upon irradiation at 350 nm the spirooxazine (SO) is transformed to the corresponding photomerocyanine (PM) that binds to DNA. After irradiation with visible light the spirooxazine, which exhibits no significant DNA-binding properties, is regained. The association of the active form of this photoswitch with DNA was examined by CD and absorption spectroscopy, fluorescent intercalator displacement and viscometric titration.
This discovery was published by the Royal Society of Chemistry:
H, Ihmels, J. Mattay, F. May, and L. Thomas, Organic & Biomolecular Chemistry, 2013, 11, 5184–5188. [10.1039/C3OB40930A]