Aziz-Lange, Ghadwal, Glaser, Godt, Hellweg, Hoge, Kohse-Höinghaus, Mitzel
Life Science Chemistry
Dierks, Fischer v. Mollard, Gröger, Hellweg, Kottke, Lübke, Niemann, Sewald
Gas Phase- und Atmospheric Chemistry
Brockhinke, Eisfeld, Kohse-Höinghaus, Koop, Manthe, Mitzel
Public Understanding of Science
Dunker, Kohse-Höinghaus, Lück, Mitzel
Important subjects in the research area Molecule-based Materials are molecular magnets, biomimetic catalysts, cytostatic compounds, fluorinated compounds, organometallic compounds, silanes, spin probes an models for EPR-spectroscopy, microgels and microemulsions.
Protein crystallography is used and sulfatases, lysosomal hydrolases and membrane transport are studied in the research area Life Science Chemistry. An additional focus are bioorganic and biocatalytic topics in organic chemistry groups, which are also investigated by biochemistry groups within the Faculty of Chemistry.
Research topics in Gas Phase- und Atmospheric Chemistry are combustion, atmospheric aerosols and ice nucleation. The core facility „gas-electron diffraction and structure analysis of small molecules“ (GED@BI, N. Mitzel) is funded by the DFG and is unique within the EU.
The research area Public Understanding of Science focuses on research concerning instructions in chemistry during early childhood.
The Faculty of Chemistry is characterized by interdisciplinary research, which is typical for Bielefeld University. Researchers in the research area Molecule-based Materials cooperate with the department of Physics.
The research area Life Science Chemistry is strengthened by cooperation with the Faculty of Biology, the Faculty of Technology and the CeBiTec.
The „Center for Molecular Materials“ CM2 is an academic department with groups from chemistry and physics (coordinator B.Hoge), which aims at connections between technical know-how of industrial partners and basic research at the university.
In addition, each group is involved in national and international research cooperations.
The efrapeptin family of peptide antibiotics produced by the fungus Tolypocladium niveum, and the neo-efrapeptins from the fungus Geotrichum candidum are inhibitors of F1-ATPase with promising antitumor, antimalaria, and insecticidal activity. They are rich in Cα-dialkyl amino acids (Aib, Iva, Acc) and contain one β-alanine and several pipecolic acid residues. The C-terminus bears an unusual heterocyclic cationic cap. The efrapeptins C—G and three analogs of efrapeptin C were synthesized using α-azido carboxylic acids as masked amino acid derivatives. All compounds display inhibitory activity toward F1-ATPase. The solution conformation of the peptides was investigated with electronic CD spectroscopy, FT-IR spectroscopy, and VCD spectroscopy. All efrapeptins and efrapeptin analogs were shown to adopt helical conformations in solution. In the case of efrapeptin C VCD spectra proved that a 310-helix prevails. In addition, efrapeptin C was conformationally studied in detail with NMR and molecular modelling. Besides NOE distance restraints, residual dipolar couplings (RDC) observed upon partial alignment with stretched PDMS gels were used for the conformational analysis and confirmed the 310-helical conformation.
S. Weigelt, T. Huber, F. Hofmann, M. Jost, M. Ritzefeld, B. Luy, C. Freudenberger, Z. Majer, E. Vass, J.C. Greie, L. Panella, B. Kaptein, Q.B. Broxterman, H. Kessler, K. Altendorf, M. Hollósi, N. Sewald, Chem. Eur. J. 2012, 18, 478–487.
Nanomagnete: von der Synthese über die Wechselwirkung mit Oberflächen zur Funktion