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Research Groups

5  Biological Systems, Dynamics of the Immune System

F. Celada (University of Genoa and NYU-Hospital for Joint Diseases, New York, NY), P. Seiden (T.J. Watson Research Laboratory, IBM, Yorktown Heights, NY)

Biographies of F. Celada and P. Seiden

FRANCO CELADA, MD, Ph.D., is Professor of Immunology at the University of Genova, Italy (since 1977); and Professor of Pathology, NYU/Senior Immunologist at the Hospital for Joint Diseases, NY (since 1987). After graduating from the University of Milano, he spent a two-year post-doctoral period at the Biology Division, Oak Ridge National Laboratory and significant research periods at the Royal Karolinska Institute in Stockolm (1963-69), at the Institut Pasteur, Paris (1969-70), and at UCLA (1975-76). He is known for his contributions on the mechanisms of graft rejection, on immunological memory and affinity maturation, on antibody-mediated enzyme activation, and on cellular cooperation influencing the immune response in normal conditions and in AIDS. His interdisciplinary interests led him to collaborate with Dr. Seiden in building a model of the immune system in the computer. Dr. Celada is a member of the American Association of Immunologists, a founding member of the Italian Group of Cooperation in Immunology and an elected member of EMBO (European Molecular Biology Organization). He is co-founder and current Secretary General of the European Association for Higher Education in Biotechnology.

PHILIP SEIDEN, Ph.D. - Since 1996 he has been a Visiting Research Collaborator in the Molecular Biology Department, Princeton University, Princeton, NJ, since 1997, a Consultant in the Department of Rheumatology, Hospital for Joint Diseases, New York, NY; and Emeritus Research Staff Member at IBM T.J. Watson Research Center, Yorktown Heights, NY. Previously he was employed at the IBM Research Center from 1960-1997 in a number of research and management positions. His research has ranged over the fields of magnetism, superconductivity, molecular science, cooperative phenomena, astrophysics and immunology. He has managed research groups in most of these areas, and held the top management positions of Director of Physical Sciences and Director of General Science. He has been Visiting Scientist at Department of Physics, Technion, Haifa, Israel (1974-75); and Visiting Associate Professor at Department of Physics, Indiana University , Bloomington, Indiana (1967-68). In 1960 he worked as National Science Foundation Postdoctoral Fellow, Institut Fourier, University of Grenoble, Grenoble, France. Dr. Seiden has been both a member and cochairman of a number of national committees under the auspices of the American Physical Society, Department of Energy, American Institute of Physics, and National Research Council.
He is a fellow of the American Physical Society and a member of the American Association for the Advancement of Sciences, American Astronomical Society, New York Academy of Sciences, and the American Association of Immunologists.


Members of the Group

(The final composition and structure will be defined in October 1999)


Work at ZiF

Immunology is the interface between theoretical and applied biological research. The Immune System has developped late in evolution: it has utilized the achievements of phylogenesis from monocellular to vertebrate and created the new genetics of somatic differentiation and interaction. Thus, Immunology is a good choice to represent the complexity of Biology at large within the present endeavour, and will both profit and contribute from exchanges with the neighbouring groups. A small number of projects, new and current, will be developed in response to the following questions:

  1. Why and how Biology may benefit from models?
  2. Why and how models may benefit from Immunology?

These opposite points of views will serve as guidelines and will offer motives for the interdisciplinary interactions with the other groups of this project at ZiF and with a number of outside consultants and visitors. The projects are:

  1. Interplay of Cellular and Humoral immune systems during the response to viruses;
  2. Modelling of Vaccination;
  3. The Isotypic Shift.

Additional topics, with special emphasis on those emphazising point of view b) are being discussed with the invited scientists and will be added shortly to the present list.


Invited Consultants



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