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Universität Bielefeld > Fakultät für Biologie > Chair of Molecular Cell Physiology > Research
  

TCP transcription factors at the interplay between the clock and downstream processes

TCP transcription factors are a family of plant-specific transcription factors that control a plethora of biological processes. They control e.g. branching in maize (Teosinthe), flower symmetry in snapdragon (Cycloidea) and cell cycle control in rice (PCF1). In the model plant Arabidopsis TCPs are involved in multiple growth processes.

Effect of TCP transcription factors on leaf growth - the plant on the right side overexpresses the microRNA miR319 and hence represses the expression of five TCP transcription factors that are targets of miR319 (jaw-D; Palatnik et al., 2003).

 

Effect of TCP20 on leaf growth - leaf cell size in early leaf growth is enhanced in tcp20 knockout plants when compared to wild type (Danisman et al., 2012).

Besides growth TCPs are also involved in the control of the circadian clock, hormone metabolism, defense against pathogens, and iron homeostasis (Andriankaja, Danisman et al., 2014).

Effect of induced TCP20 activity on target genes - Dexamethasone induction of TCP20-GR construct in tcp20 knockout background leads to repression of the bHLH transcription factors bHLH38, bHLH39, bHLH100 and bHLH101 (Andriankaja, Danisman et al., 2014).

We are elucidating the role of TCPs at the intersections between the circadian clock and other biological processes, both using wet lab techniques and bioinformatics approaches.

We are always glad to welcome new people to our group and want to invite interested students with bioinformatics and/or molecular biology backgrounds to join us in tackling our research questions.

Interested students please contact
selahattin.danisman@uni-bielefeld.de