Fakultät für Chemie - Department of Chemistry
 
 
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Bielefeld University > Department of Chemistry

Absolventenfeier 2014 /  Neues Praktikum  
Absolventenfeier 2014

Am Freitag den 5. Dezember 2014 findet die Absolventenfeier statt.

Weitere Infos zum Programm gibt es hier:
Absolventenfeier 2014...

Finanzspritze für die Bielefelder Chemie

Der Fonds der Chemischen Industrie unterstützt die Fakultät für Chemie der Universität Bielefeld mit 84000 € zur Neuetablierung des Praktikums Biokatalyse in der stereoselektiven Synthese. Weiterlesen...

[Pressemitteilung des Fonds der Chemischen Industrie]


Current work from our research groups 


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Cryptophycins are a family of antimitotic depsipeptides with very high cytotoxicity even against multi-drug resistant (MDR) cancer cells.
The first representative was isolated from cyanobacteria Nostoc sp. in 1990. Their bioactivity is based on their interaction with the protein tubulin. Cryptophycins were found to induce apoptosis due to inhibition of the microtubule dynamics. Consequently, cryptophycin analogues are considered as potential antitumour agents. Retrosynthetically, cryptophycins can be subdivided into four building blocks, namely units A–D, to be assembled in the total synthesis. Since the discovery of this compound class, numerous synthetic analogues have been designed for structure-activity relationship (SAR) studies.
The Sewald group published a critical overview on cryptophycins in the renowned journal Natural Product Reports. The main focus lies on the synthetic challenges of recently published cryptophycins, together with emerging concepts on cryptophycin bioconjugation and prodrug design.


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Modellbasierte Regelung der homogenisierten Niedertemperatur-Verbrennung



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Nanomagnete: von der Synthese über die Wechselwirkung mit Oberflächen zur Funktion