2017 / 2016 / 2015 / 2014 / 2013 / 2012 / 2011 / 2010 / 2009 / 2008 / 2007 / 2006 /

2005 / 2004 / 2003 / 2002 / 2001 / 2000 / 1999 / 1998 / 1997 / 1996 / 1995


158. P. Rommelmann, T. Betke, H. Gröger
Synthesis of Enantiomerically Pure N-Acyl Amino Nitriles via Catalytic Dehydration of Oximes and Application in a de Novo Synthesis of Vildagliptin
Org. Process Res. Dev. 2017, 21,1521-1527.
157. T. Betke, P. Rommelmann, K. Oike, Y. Asano, H. Gröger
Cyanide-Free and Broadly Applicable Enantioselective Synthetic Platform for Chiral Nitriles through a Biocatalytic Approach
Angew. Chem. 2017, 129,12533-12538; Angew. Chem. Int. Ed. 2017, 56,12361-12366.
156. H. Gröger, M. Pieper, B. König, T. Bayer, H. Schleich
Industrial Landmarks in the Development of Sustainable Production Processes for the beta-Lactam Antibiotic Key Intermediate 7-Aminocephalosporanic Acid (7-ACA)
Sustainable Chem. Pharm. 2017, 5, 72-79.
155. M. Heidlindemann, A. Berkessel, H. Gröger
"Side-Product Catalysis": Substrate Autoxidation as an Overlooked Side Reaction Generating a Co-Catalyst for Enhancing Asymmetric Aldol Reactions
ChemCatChem 2017, 9, 1383-1388.
154. C. Scherkus, S. Schmidt, U. T. Bornscheuer, H. Gröger, S. Kara, A. Liese
Kinetic insights into epsilon-caprolactone synthesis: Improvement of an enzymatic cascade reaction
Biotechnol. Bioeng. 2017, 114, 1215-1221.
153. N. Zumbrägel, D. Wetzl, H. Iding, H. Gröger
Asymmetric Biocatalytic Reduction of Cyclic Imines: Design and Application of a Tailor-Made
Whole-Cell Catalyst
Heterocycles 2017, 95, 1261-1271.
152. K. Hahn, K. Neumeister, A. Mix, T. Kottke, H. Gröger, G. Fischer von Mollard
Recombinant expression and characterization of a L-amino acid oxidase from the fungus Rhizoctonia solani
Appl. Microbiol. Biotechnol. 2017, 101, 2853-2864.
151. S. Wedde, P. Rommelmann, C. Scherkus, S. Schmidt, U. T. Bornscheuer, A. Liese, H. Gröger
An alternative approach towards poly-e-caprolactone through a chemoenzymatic synthesis: combined hydrogenation, bio-oxidations and polymerization without the isolation of intermediates
Green Chemistry 2017, 19, 1286-1290.
150. F. Uthoff, A. Reimer, A. Liese, H. Gröger
Enzymatic resolution of an amine under solvent-free conditions with diethyl malonate as reagent for acylation
Sustainable Chemistry and Pharmacy 2017, 5, 42-45.
149. F. Uthoff, H. Sato, H. Gröger
Formal Enantioselective Hydroamination of Non-Activated Alkenes: Transformation of Styrenes into Enantiomerically Pure 1-Phenylethylamines in Chemoenzymatic One-Pot Synthesis
ChemCatChem 2017, 9, 555-558.
148. G. Rulli, N. Duangdee, W. Hummel, A. Berkessel, H. Gröger
First Tandem-Type One-Pot Process Combining Asymmetric Organo- and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3-Diols
Eur. J. Org. Chem. 2017, 812-817.
147. A. Reimer, S. Wedde, S. Staudt, S. Schmidt, D. Höffer, W. Hummel, U. Kragl, U. T. Bornscheuer, H. Gröger
Process Development through Solvent Engineering in the Biocatalytic Synthesis of the Heterocyclic Bulk Chemical epsilon-Caprolactone
J. Heterocycl. Chem. 2017, 54, 391-396.
146. M. Biermann, D. Bakonyi, W. Hummel, H. Gröger
Design of recombinant whole-cell catalysts for double reduction of C=C and C=O bonds in enals and application in the synthesis of Guerbet alcohols as industrial bulk chemicals for lubricants
Green Chem. 2017, 19, 405-410.


145. C. Scherkus, S. Schmidt, U. T. Bornscheuer, H. Gröger, S. Kara, A. Liese
A Fed-Batch Synthetic Strategy for a Three-Step Enzymatic Synthesis of Poly-epsilon-caprolactone
ChemCatChem 2016, 8, 3446-3452.
144. C. A. Müller, A. M. Weingartner, A. Dennig, A. J. Ruff, H. Gröger, U. Schwaneberg
A Whole Cell Biocatalyst for Double Oxidation of Cyclooctane
J. Ind. Microbiol. Biotechnol. 2016, 43, 1641-1646.
143. A. Gómez Baraibar, D. Reichert, C. Mügge, S. Seger, H. Gröger, R. Kourist
A One-Pot Cascade Reaction Combining an Encapsulated Decarboxylase with a Metathesis Catalyst for the Synthesis of Bio-Based Antioxidants
Angew. Chem. 2016, 128,15043-15047; Angew. Chem. Int. Ed. 2016, 55,14823-14827.
142. H. Gröger
"Shibasaki Catalysts and Their Use for Asymmetric Synthetic Applications by the Chemical Industry"
Eur. J. Org. Chem. 2016, 4116-4123.
141. D. Bulut, N. Duangdee, H. Gröger, A. Berkessel, W. Hummel
"Screening, Molecular Cloning, and Biochemical Characterization of an Alcohol Dehydrogenase from Pichia pastoris Useful for the Kinetic Resolution of a Racemic β-Hydroxy-β-trifluoromethyl Ketone"
ChemBioChem. 2016, 17,1349-1358.
140. H. Gröger, W. Hummel, S. Wedde
"Asymmetric Synthesis with Recombinant Whole-Cell Catalyst"
Green Biocatalysis (ed.: R. N. Patel), John Wiley & Sons, Hoboken, New Jersey, 2016, Chapter 23, p. 557-585.
139. M. Biermann, H. Gruß, W. Hummel, H. Gröger
Guerbet Alcohols: From Processes under Harsh Conditions to Synthesis at Room Temperature under Ambient Pressure
ChemCatChem 2016, 8,895-899.
138. H. Gröger
Practical and Engineering Aspects of Running Enzyme Reactions
Organic Synthesis Using Biocatalysis (eds.: A. Goswami, J. D. Stewart), Elsevier, Amsterdam, Oxford, Waltham, 2016, Chapter 2, pp. 39-66.


137. S. Schmidt, H. C. Büchsenschütz, C. Scherkus, A. Liese, H. Gröger, U. T. Bornscheuer
Biocatalytic Access to Chiral Polyesters by an Artifical Enzyme Cascade Synthesis
ChemCatChem 2015, 7, 3951-3955.
136. W. Greschner, B. Neumann, H.-G. Stammler, H. Gröger, D. Kuck
Enantiomerically Pure Tribenzotriquinacenes through Stereoselective Synthesis
Angew. Chem. 2015, 127, 13968-13972; Angew. Chem.Int.Ed. 2015, 54, 13764-13768.
135. J. Tomasek, M. Sessler, H. Gröger, J. Schatz
Olefin metathesis reaction in water and in air improved by supramolecular additives
Molecules. 2015, 20, 19130-19141.
134. D. Bulut, H. Gröger, W. Hummel
Development of a Growth-Dependent Selection System for Identification of L-Threonine Aldolases
Appl. Microbiol. Biotechnol. 2015, 99, 5875-5883.
133. R. Metzner, W. Hummel, F. Wetterich, B. König, H. Gröger
Integrated Biocatalysis in Multistep Drug Synthesis without Intermediate Isolation:
A de Novo Approach toward a Rosuvastatin Key Building Block
Org. Process Res. Dev. 2015, 19, 635-638.
132. S. Takizawa, H. Gröger, H. Sasai
Vanadium in Asymmetric Synthesis: Emerging Concepts in Catalyst Design and Applications
Chem. Eur. J. 2015, 21, 8992-8997.
131. T. Reß, W. Hummel, S. P. Hanlon, H. Iding, H. Gröger
The Organic-Synthetic Potential of Recombinant Ene Reductases: Substrate-Scope Evaluation
and Process Optimization
ChemCatChem 2015, 7, 1302-1311.
130. M. Heidlindemann, M. Hammel, U. Scheffler, R. Mahrwald, W. Hummel, A. Berkessel, H. Gröger
Chemoenzymatic Synthesis of Vitamin B5-Intermediate (R)-Pantolactone via Combined Asymmetric
Organo- and Biocatalysis
J. Org. Chem. 2015, 80, 3387-3396.
129. H. Sato, W. Hummel, H. Gröger
Cooperative Catalysis of Noncompatible Catalysts through Compartmentalization: Wacker Oxidation and Enzymatic Reduction in a One-Pot Process in Aqueous Media
Angew. Chem. 2015, 127, 4570-4574; Angew.Chem.Int.Ed. 2015, 54, 4488-4492.
128. H. Gröger
Metals and Metal Complexes in Cooperative Catalysis with Enzymes within Organic-Synthetic
One-Pot Processes
Cooperative Catalysis (Hrsg.: R. Peters), Wiley-VCH, Weinheim. 2015, Kapitel 11, S., 325-349.
127. S. Schmidt, C. Scherkus, J. Muschiol, U. Menyes, T. Winkler, W. Hummel, H. Gröger, A. Liese, H.-G. Herz,
U. T. Bornscheuer
An Enzyme Cascade Synthesis of ε-Caprolactone and its Oligomers
Angew.Chem. 2015, 127, 2825-2828; Angew.Chem.Int.Ed. 2015, 54, 2784-2787.
126. K. Tenbrink, I. Kemker, J. Schatz, H. Gröger
Synthesis of Substituted Cycloalkene-1,1-dicarboxylates via Olefin Metathesis in Water
ARKIVOC 2015, (ii), 10-19.
125. P. Böhm, H. Gröger
Iron(III)-Porphyrin Complex FeTSPP: A Versatile Water-Soluble Catalyst for Oxidations in Organic Syntheses, Biorenewables Degradations and Environmental Applications
ChemCatChem 2015, 7, 22-28.
124. H. Gröger, W. Hummel
Merging of Metal, Organic, and Enzyme Catalysis
in: Science of Synthesis, Biocatalysis in Organic Synthesis(Hrsg.: K. Faber, W.-D. Fessner, N. J. Turner), Band 3, Thieme, Stuttgart, 2015, Kapitel 3.8.2, 491-514.


123. C. A. Müller, A. Dennig, T. Welters, T. Winkler, A. J. Ruff, W. Hummel, H. Gröger, U. Schwaneberg
Whole-Cell Double Oxidation of n-Heptane
J. Biotechnol. 2014, 191, 196-204.
122. W. Hummel, H. Gröger
Strategies for Regeneration of Nicotinamide Coenzymes Emphasizing Self-Sufficient Closed-Loop Recycling Systems
J. Biotechnol. 2014, 191, 22-31.
121. R. Metzner, S. Okazaki, Y. Asano, H. Gröger
Cyanide-Free Enantioselective Synthesis of Nitriles: Synthetic Proof of a Biocatalytic Concept and Mechanistic Insights
ChemCatChem 2014, 6, 3105-3109.
120. M. Alfaro Blasco, H. Gröger
Enzymatic Resolution of Racemates with a "Remote" Stereogenic Center as an Efficient Tool in Drug, Flavor and Vitamin Synthesis
Bioorg. Med. Chem. 2014, 22, 5539-5546.
119. H. Gröger, W. Hummel
Chemoenzymatic Multistep One-Pot Processes
Cascade Biocatalysis (eds.: S. Riva, W.-D. Fessner), Wiley-VCH, Weinheim, 2014, 19, 427-456.
118. H. Gröger, W. Hummel
Combining the " two worlds" of chemocatalysis and biocatalysis towards multi-step one-pot processes in aqueous media
Curr. Opin. Chem. Biol. 2014, 19, 171-179.
117. M. Heidlindemann, G. Rulli, A. Berkessel, W. Hummel, H. Gröger
Combination of Asymmetric Organo- and Biocatalytic Reactions in Organic Media Using Immobilized Catalysts in Different Compartments
ACS Catal. 2014, 4, 1099-1103.
116. W. Greschner, C. Lanzerath, T. Ress, K. Tenbrink, S. Borchert, A. Mix, W. Hummel, H. Gröger
Artificial Cofactor Regeneration with an Iron(III)porphyrin as NADH-Oxidase Mimic in the Enzymatic Oxidation of l-Glutamate to α-Ketoglutarate
J. Mol. Cat. B: Enzym 2014, 103, 10-15.
115. H. Gröger
Hydroxy Functionalization of Non-Activated C-H and C=C Bonds: New Perspectives for the Synthesis of Alcohols through Biocatalytic Processes
Angew. Chem. 2014, 126, 3128-3130; Angew. Chem. Int. Ed. 2014, 53, 3067-3069.
114. T. Winkler, H. Gröger, W. Hummel
Enantioselective Rearrangement Coupled with Water Addition: Direct Synthesis of Enantiomerically Pure Saturated Carboxylic Acids from α,β-Unsaturated Aldehydes
ChemCatChem 2014, 6, 961-964.


113. G. Rulli, M. Heidlindemann, A. Berkessel, W. Hummel, H. Gröger
Towards Catalyst Compartimentation in Combined Chemo- and Biocatalytic Processes: Immobilization of Alcohol Dehydrogenases for the Diastereoselective Reduction of a b-Hydroxy Ketone Obtained from an Organocatalytic Aldol Reaction
J. Biotechnol. 2013, 168, 271-276.
112. G. Rulli, K. A. Fredriksen, N. Duangdee, T. Bonge-Hansen, A. Berkessel, H. Gröger
Asymmetric Organocatalytic Aldol Reaction in Water: Mechanistic Insights and Development of a Semi-Continuously-Operating Process
Synthesis 2013, 45, 2512-2519.
111. S. Strompen, M. Weiß, H. Gröger, L. Hilterhaus, A. Liese
Development of a Continuously Operating Process for the Enantioselective Synthesis of a β-Amino Acid Ester via a Solvent-Free Chemoenzymatic Reaction Sequence
Adv. Synth. Catal. 2013, 355, 2391-2399.
110. E. Burda, T. Reß, T. Winkler, C. Giese, X. Kostrov, T. Huber, W. Hummel, H. Gröger
Enantioselective Enoatreductase-Catalyzed Synthesis of α-Branched Nitroalkanes
Angew. Chem. 2013, 125, 9493-9496; Angew. Chem. Int. Ed. 2013, 52, 9323-9326.
109. C. A. Müller, B. Akkapurathu, T. Winkler, S. Staudt, W. Hummel, H. Gröger, U. Schwaneberg
In Vitro Double-Oxidation of n-Heptane with Direct Co-Factor Regeneration
Adv. Synth. Catal. 2013, 355, 1787-1798.
108. S. Staudt, U. Menyes, U. T., Bornscheuer, H. Gröger
Direct Biocatalytic One-Pot-Transformation of Cyclohexanol with Molecular Oxygen into epsilon-Caprolactone
Enzyme Microb. Technol. 2013, 53, 288-292.
107. S. Staudt, E. Burda, C. Giese, C. A. Müller, J. Marienhagen, U. Schwaneberg, W. Hummel, K. Drauz, H. Gröger
Direktoxidation von Cycloalkanen zu Cycloalkanonen mit Sauerstoff in Wasser
Angew. Chem. 2013, 125, 2415-2419; Angew. Chem. Int. Ed. 2013, 52, 2359-2363.
106. M. Alfaro Blasco, H. Gröger
Organocatalytic Racemization of α-Aryl Propionates in the Presence of Water
Synth. Commun. 2013, 43, 9-15.


105. S. Simon, S. Oßwald, J. Roos, H. Gröger
Efficient Enzymatic Amine Resolution at High Substrate Input Using Diethyl Malonate as an Acyl Donor of Low Hazard Potential
Z. Naturforsch. 2012, 67b, 1123-1126.
104. H. Gröger, W. Hummel, R. Metzner
Reduction: Asymmetric Biocatalytic Reduction of Ketones in:
Synthetic Methods / Comprehensive Chirality (Hrsg.: E. M. Carreira, H. Yamamoto),
Band 7, Elsevier, Amsterdam 2012, Kapitel 7.10, S. 181-215.
103. S. Borchert, E. Burda, J. Schatz, W. Hummel, H. Gröger
Combination of a Suzuki cross-coupling reaction using a water-soluble palladium catalyst with an asymmetric enzymatic reduction towards a one-pot process in aqueous medium at room temperature
J. Mol. Cat. B: Enzym. 2012, 84, 89-93.
102. N. Duangdee, W. Harnying, G. Rulli, J.-M. Neudörfl, H. Gröger, A. Berkessel
Highly Enantioselective Organocatalytic Trifluoromethyl Carbinol Synthesis-A Caveat on Reaction Times and Product Isolation
J. Am. Chem. Soc. 2012, 134, 11196-11205.
101. S. Strompen, M. Weiß, T. Ingram, I. Smirnova, H. Gröger, L. Hilterhaus, A. Liese
Kinetic investigation of a solvent-free, chemoenzymatic reaction sequence towards enantioselective synthesis of a β-amino acid ester
Biotechnol. Bioengin. 2012, 109, 1479-1489
100. H. Gröger, Y. Asano, U. T. Bornscheuer, J. Ogawa
Development of Biocatalytic Processes in Japan and Germany: From Research Synergies to Industrial Applications
Chem. Asian J. 2012, 7, 1138-1153.
99. A. Prechter, H. Gröger, M. R. Heinrich
Synthesis of (S)-(+)-cericlamine through lipase-catalyzed aminolysis of azo acetates
Org. Biomol. Chem. 2012, 10, 3384-3387.
98. M. Weiß, S. Borchert, E. Rémond, S. Jugé, H. Gröger
Asymmetric Addition of a Nitrogen Nucleophile to an Enoate in the Presence of a Chiral Phase-Transfer Catalyst: A Novel
Approach toward Enantiomerically Enriched Protected β-Amino Acids Heteroatom Chem. 2012, 23, 202-209.
97. W. Hummel, H. Gröger
Reductive Amination of Keto Acids
Enzyme Catalysis in Organic Synthesis (Hrsg.: K. Drauz, H. Gröger, O. May), 3. Auflage, Band 2, Wiley-VCH, Weinheim 2012, Kapitel 28, S. 1165-1203.
96. H. Gröger, W. Hummel, S. Borchert, M. Kraußer
Reduction of Ketones and Aldehydes to Alcohols
Enzyme Catalysis in Organic Synthesis (Hrsg.: K. Drauz, H. Gröger, O. May), 3. Auflage, Band 2, Wiley-VCH, Weinheim 2012, Kapitel 26, S. 1037-1110.
95. M. Paravidino, P. Böhm, H. Gröger, U. Hanefeld
Hydrolysis and Formation of Carboxylic Acid Esters
Enzyme Catalysis in Organic Synthesis (Hrsg.: K. Drauz, H. Gröger, O. May), 3. Auflage, Band 1, Wiley-VCH, Weinheim 2012, Kapitel 8, S. 251-362.
94. H. Gröger, Y. Asano
Introduction - Principles and Historical Landmarks of Enzyme Catalysis in Organic Synthesis
Enzyme Catalysis in Organic Synthesis (Hrsg.: K. Drauz, H. Gröger, O. May), 3. Auflage, Band 1, Wiley-VCH, Weinheim 2012, Kapitel 1, S. 3-42.
93. S. Staudt, C. A. Müller, J. Marienhagen, C. Böing, S. Buchholz, U. Schwaneberg, H. Gröger
Biocatalytic Hydroxylation of n-Butane with In Situ Cofactor Regeneration at Low Temperature and under Normal Pressure
Beilstein J. Org. Chem. 2012, 8, 186-191.
92. I. Schnapperelle, W. Hummel, H. Gröger
Formal Asymmetric Hydration of Non-Activated Alkenes in Aqueous Medium through a "Chemoenzymatic Catalytic System"
Chem. Eur. J. 2012, 18, 1073-1076.
91. A. Berkessel, W. Harnying, N. Duangdee, J.-M. Neudörfl, H. Gröger
Large-Scale Synthesis of Singh‘s Catalyst in a One-Pot Procedure Starting from Proline
Org. Proc. Res. Developm. 2012, 16, 123-128.


90. K. Tenbrink, M. Seßler, J. Schatz, H. Gröger
Combination of Olefin Metathesis and Enzymatic Ester Hydrolysis in Aqueous Media in a One-Pot Synthesis
Adv. Synth. Catal. 2011, 353, 2363-2367.
89. G. Rulli, N. Duangdee, K. Baer, W. Hummel, A. Berkessel, H. Gröger
Direction of Kinetically versus Thermodynamically Controlled Organocatalysis and Its Application in Chemoenzymatic Synthesis
Angew. Chem. 2011, 123, 8092-8095; Angew. Chem. Int. Ed. 2011, 50, 7944-7947.
88. K. Baer, N. Dückers, T. Rosenbaum, C. Leggewie, S. Simon, M. Kraußer, S. Oßwald, W. Hummel, H. Gröger
A Study Towards Efficient L-Threonine Aldolase-Catalyzed Enantio- and Diastereoselective Aldol Reactions of Glycine with Substituted Benzaldehydes: Biocatalyst Production and Process Development
Tetrahedron: Asymmetry 2011, 22, 925-928.
87. H. Maid, P. Böhm, S. M. Huber, W. Bauer, W. Hummel, N. Jux, H. Gröger
Iron Catalysis for In Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen: A Synthetic Metalloporphyrin as a Biomimetic NAD(P)H Oxidase
Angew. Chem. 2011, 123, 2445-2448; Angew. Chem. Int. Ed. 2011, 50, 2397-2400.
86. M. Kraußer, T. Winkler, N. Richter, S. Dommer, A. Fingerhut, W. Hummel, H. Gröger
Combination of C=C Bond Formation by Wittig Reaction and Enzymatic C=C Bond Reduction in a One-Pot Process in Water
ChemCatChem 2011, 3, 293-296.
85. F. R. Dietz, A. Prechter, H. Gröger, M. Heinrich
Chiral azo compounds: enantioselective synthesis and transformations into β-amino alcohols and α-amino acids with a quaternary stereocenter
Tetrahedron Lett. 2011, 52, 655-657.
84. N. Richter, H. Gröger, W. Hummel Asymmetric reduction of activated alkenes using an enoate reductase from Gluconobacter oxydans
Appl. Microbiol. Biotechnol. 2011, 89, 79-89.


83. N. Dückers, K. Baer, S. Simon, H. Gröger, W. Hummel
Threonine aldolases-screening, properties and applications in the synthesis of non-proteinogenic β-hydroxy-α-amino acids
Appl. Microbiol. Biotechnol. 2010, 88, 409-424.
82. M. Weiß, T. Brinkmann, H. Gröger
Towards a greener synthesis of (S)-3-aminobutanoic acid: process development and environmental assessment
Green Chem. 2010, 12, 1580-1588.
81. P. Bauer, J. Munkert, M. Brydziun, E. Burda, F. Müller-Uri, H. Gröger, Y. A. Muller, W. Kreis
Highly Conserved Progesterone 5β-Reductase Genes (P5βR) from 5Cardenolide-Free and 5β-Cardenolide-Producing Angiosperms
Phytochemistry 2010, 71, 1495-1505.
80. M. Alfaro Blasco, S. Thumann, J. Wittmann, A. Giannis, H. Gröger
Enantioselective Biocatalytic Synthesis of (S)-Monastrol
Bioorg. Med. Chem. Lett. 2010, 20, 4679-4682.
79. K. Baer, N. Dückers, W. Hummel, H. Gröger
Expanding the Application Range of Aldolases: Novel Asymmetric Syntheses of α-Methylated β-Hydroxy α-Amino Acids and β-Amino Alcohols
ChemCatChem 2010, 2, 939-942.
78. A. Weckbecker, H. Gröger, W. Hummel
Regeneration of Nicotinamide Coenzymes: Principles and Applications for the Synthesis of Chiral Compounds
Adv. Biochem. Engin./Biotechnol. 2010, 120, 195-242.
77. J. Parkot, H. Gröger, W. Hummel
Purification, Cloning and Overexpression of an Alcohol Dehydrogenase from Nocardia globerula Reducing Aliphatic Ketones and Bulky Ketoesters
Appl. Microbiol. Biotechnol. 2010, 86, 1813-1820.
76. H. Gröger, S. Borchert, M. Kraußer, W. Hummel
Enzyme-Catalyzed Asymmetric Reduction of Ketones
Encyclopedia of Industrial Biotechnology. Bioprocess, Bioseparation, and Cell Technology (Ed.: M. Flickinger), John Wiley & Sons, New York 2010, p. 2094-2110.
75. A. Neupert, T. Ress, J. Wittmann, W. Hummel, H. Gröger
Enantioselective Biocatalytic Reduction of Nonprotected Hydroxyacetophenones
Z. Naturforsch. 2010, 65b, 337-340.
74. H. Gröger
Enzyme-Catalyzed Asymmetric Synthesis
Catalytic Asymmetric Synthesis (Ed.: I. Ojima), 3. Auflage, John Wiley & Sons, Hoboken, New Jersey 2010, chapter 6, p. 269-341.
73. E. Burda, W. Bauer, W. Hummel, H. Gröger
Enantio- and Diastereoselective Chemoenzymatic Synthesis of C2-Symmetric Biaryl-Containing Diols
ChemCatChem 2010, 2, 67-72.


72. F. R. Dietz, H. Gröger
Asymmetric Synthesis of All Stereoisomers of α-Methylthreonine Using an Organocatalytic Steglich Rearrangement Reaction as a Key Step
Synthesis 2009, 4208-4218.
71. E. Burda, M. Kraußer, G. Fischer, W. Hummel, F. Müller-Uri, W. Kreis, H. Gröger
Recombinant Δ4,5-Steroid 5β-Reductases as Biocatalysts for the Reduction of Activated C=C-Double Bonds in Monocyclic and Acyclic Molecules
Adv. Synth. Catal. 2009, 351, 2787-2790.
70. K. Baer, M. Kraußer, E. Burda, W. Hummel, A. Berkessel, H. Gröger
Sequential and Modular Synthesis of Chiral 1,3-Diols with Two Stereogenic Centers: Access to All Four Stereoisomers by Combination of Organo- and Biocatalysis
Angew. Chem. 2009, 121, 9519-9522; Angew. Chem. Int. Ed. 2009, 48, 9355-9358.
69. M. Weiß, H. Gröger
Practical, Highly Enantioselective Chemoenzymatic One-Pot Synthesis of Short-Chain Aliphatic β-Amino Acid Esters
Synlett 2009, 1251-1254.
68. H. Gröger, F. R. Dietz
Biocatalytic Synthesis of Natural and Non-Natural α-Amino Acids
Wiley Encyclopedia of Chemical Biology (Ed.: T. P. Begley), Volume 1, John Wiley & Sons, Hoboken 2009, p. 191-204.


67. E. Burda, W. Hummel, H. Gröger
Modular Chemoenzymatic One-Pot Syntheses in Aqueous Media: Combination of a Palladium-Catalyzed Cross-Coupling with an Asymmetric Biotransformation
Angew. Chem. 2008, 120, 9693-9696; Angew. Chem. Int. Ed. 2008, 47, 9551-9554.
66. H. Gröger, E. Burda
Chiral Trivalent Phosphorus Compounds as Organocatalysts in Asymmetric Synthesis
Phosphorous Ligands in Asymmetric Catalysis - Synthesis and Applications (Ed.: A. Börner), Band 3, Wiley-VCH, Weinheim 2008, chapter 10.1, p. 1175-1197.
65. H. Gröger
Asymmetric Organocatalysis on a Technical Scale: Current Status and Future Challenges
Ernst Schering Foundation Symposium Proceedings 2007-2: Organocatalysis (Ed.: M. T. Reetz, B. List, S. Jaroch; H. Weinheim), Springer-Verlag, Berlin, Heidelberg 2008, p. 141-158.
64. F. R. Dietz, H. Gröger
Novel Catalytic Synthetic Route to Protected α-Methyl Threonine and the First Asymmetric Acetyl Migration in a Steglich Rearrangement Reaction
Synlett 2008, 663-666.
63. P. Dominguez de Maria, T. Stillger, M. Pohl, M. Kiesel, A. Liese, H. Gröger, H. Trauthwein
Enantioselective C-C Bond Ligation Using Recombinant Escherichia coli-Whole-Cell Biocatalysts
Adv. Synth. Catal. 2008, 350, 165-173.


62. S. Osswald, K. Doderer, H. Gröger, W. Wienand
Alcohol dehydrogenase whole-cell catalysts - A broad technology platform for life science applications
Chimica Oggi - Chemistry Today 2007, 25(5,S), 16-18.
61. M. Kraußer, W. Hummel, H. Gröger
Enantioselective One-Pot Two-Step Synthesis of Hydrophobic Allylic Alcohols in Aqueous Medium Through the Combination of a Wittig Reaction and an Enzymatic Ketone Reduction
Eur. J. Org. Chem. 2007, 5175-5179.
60. A. Berkessel, C. Rollmann, F. Chamouleau, S. Labs, O. May, H. Gröger
Practical Two-Step Synthesis of an Enantiopure Aliphatic Terminal (S)-Epoxide Based on Reduction of Haloalkanones with "Designer Cells"
Adv. Synth. Catal. 2007, 349, 2697-2704.
59. H. Gröger, C. Rollmann, F. Chamouleau, I. Sebastien, O. May, W. Wienand, K. Drauz
Enantioselective Reduction of 4-Fluoroacetophenone at High Substrate Concentration Using a Tailor-Made Recombinant Whole-Cell Catalyst
Adv. Synth. Catal. 2007, 349, 709-712.
58. P. Dominguez de Maria, M. Pohl, D. Gocke, H. Gröger, H. Trauthwein, T. Stillger, L. Walter, M. Müller
Asymmetric Synthesis of Aliphatic 2-Hydroxy Ketones by Enzymatic Carboligation of Aldehydes
Eur. J. Org. Chem. 2007, 2940-2944.
57. F. Chamouleau, C. Hagedorn, O. May, H. Gröger
Biocatalytic Aldehyde Reduction Using Tailor-Made Whole-Cell Catalysts: A Novel Synthesis of the Aroma Chemical Cinnamyl Alcohol
Flavour Fragr. J. 2007, 22, 169-172.


56. S. Buchholz, H. Gröger
Biocatalytic Concepts for the Synthesis of Optically Active Amines
Biocatalysis in the Pharmaceutical and Biotechnology Industries (Ed.: R. N. Patel), CRC Press, New York 2006, chapter 34, p. 829-847.
55. S. Buchholz, H. Gröger
Enantioselective Biocatalytic Reduction of Ketones for the Synthesis of Optically Active Alcohols
Biocatalysis in the Pharmaceutical and Biotechnology Industries (Ed.: R. N. Patel), CRC Press, New York 2006, chapter 32, p. 757-790.
54. H. Gröger, F. Chamouleau, N. Orologas, C. Rollmann, K. Drauz, W. Hummel, A. Weckbecker, O. May
Enantioselective Reduction of Ketones with "Designer Cells" at High Substrate Concentrations: Highly Efficient Access to Functionalized Optically Active Alcohols
Angew. Chem. 2006, 118, 5806-5809; Angew. Chem. Int. Ed. 2006, 45, 5677-5681.
53. H. Gröger, O. May, H. Hüsken, S. Georgeon, K. Drauz, K. Landfester
Enantioselective Enzymatic Reactions in Miniemulsions as Efficient "Nanoreactors"
Angew. Chem. 2006, 118, 1676-1679; Angew. Chem. Int. Ed. 2006, 45, 1645-1648.
52. H. Gröger, O. May, H. Werner, A. Menzel, J. Altenbuchner
A "Second Generation-Process" for the Synthesis of L-Neopentylglycine: Asymmetric Reductive Amination Using a Recombinant Whole Cell Catalyst
Org. Proc. Res. Developm. 2006, 10, 666-669.
51. P. Dominguez de Maria, T. Stillger, M. Pohl, S. Wallert, K. Drauz, H. Gröger, H. Trauthwein, A. Liese
Preparative Enantioselective Synthesis of Benzoins and (R)-2-Hydroxy-1-phenyl-propanone Using Benzaldehyde Lyase
J. Mol. Catal. B: Enzym. 2006, 38, 43-47.


50. S. Buchholz, H. Gröger
Angewandte Mikrobiologie, Ed.: G. Antranikian, Springer Verlag, Heidelberg 2005, chapter 8, p. 161-172.
49. S. Wallert, K. Drauz, I. Grayson, H. Gröger, P. Dominguez de Maria, C. Bolm
Ionic liquids as Additives in the Pig Liver Esterase (PLE) Catalyzed Synthesis of Chiral Disubstituted Malonates
Green Chem. 2005, 7, 602-605.
48. P. Dominguez de Maria, B. Kossmann, N. Potgrave, S. Buchholz, H. Trauthwein, O. May, H. Gröger
Improved Process for the Enantioselective Hydrolysis of Prochiral Diethyl Malonates Catalyzed by Pig Liver Esterase
Synlett 2005, 1746-1748.
47. A. Berkessel, H. Gröger
Asymmetric Organocatalysis, Wiley-VCH Verlag, Weinheim 2005.


46. A. Menzel, H. Werner, J. Altenbuchner, H. Gröger
From Enzymes to "Designer Bugs" in Reductive Amination: A New Process for the Synthesis of L-tert-Leucine Using a Whole Cell-Catalyst
Eng. Life Sciences 2004, 4, 573-576.
45. H. Gröger, H. Trauthwein, S. Buchholz, K. Drauz, C. Sacherer, S. Godfrin, H. Werner
The First Aminoacylase-Catalyzed Enantioselective Synthesis of Aromatic β-Amino Acids
Org. Biomol. Chem. 2004, 2, 1977-1978.
44. H. Gröger, W. Hummel, C. Rollmann, F. Chamouleau, H. Hüsken, H. Werner, C. Wunderlich, K. Abokitse, K. Drauz, S. Buchholz
Preparative Asymmetric Reduction of Ketones in a Biphasic Medium with an (S)-Al-cohol Dehydrogenase under in situ-Cofactor-Recycling with a Formate Dehydrogenase
Tetrahedron 2004, 60, 633-640.
43. O. May, H. Gröger
Enzymatic Cofactor-Regeneration Technology Platforms for Chiral α-Amino Acids and Alcohols
Speciality Chemicals Magazine 2004, (5), 24-25.
42. M. Shibasaki, M. Kanai, H. Gröger
Nitroaldol Reaction
Comprehensive Asymmetric Catalysis, Supplement, Eds.: E. Jacobsen, A. Pfaltz, H. Yamamoto, Volume 1, Springer-Verlag, Heidelberg 2004, p. 131-133.
41. H. Gröger, K. Drauz
Methods for the Biocatalytic Production of L-Amino Acids on Industrial Scale
Large-Scale Asymmetric Catalysis, Eds.: E. Schmidt, H. U. Blaser, Wiley-VCH Verlag, Weinheim 2004, chapter 1.8, p. 131-147.


40. H. Gröger
Catalytic Enantioselective Strecker Reactions and Analogous Syntheses
Chem. Rev. 2003, 103, 2795-2827.
39. H. Gröger, W. Hummel, S. Buchholz, K. Drauz, T. V. Nyugen, C. Rollmann, H. Hüsken, K. Abokitse
Practical Asymmetric Enzymatic Reduction through Discovery of a Dehydrogenase-Compatible Biphasic Reaction Media
Org. Lett. 2003, 5, 173-176.
38. W. Hummel, K. Abokitse, K. Drauz, C. Rollmann, H. Gröger
Towards a Large-Scale Asymmetric Reduction Process with Isolated Enzymes: Expression of an (S)-Alcohol Dehydrogenase in E. coli and Studies on the Synthetic Potential of this Biocatalyst
Adv. Synth. Catal. 2003, 345, 153-159.
37. H. Gröger, J. Wilken, A. Berkessel
Simple Amino acids and Short-chain Peptides as Efficient Metal-free Catalysts in Asymmetric Synthesis
Organic Synthesis Highlights V, Eds.: H. Schmalz, T. Wirth, Wiley-VCH Verlag, Weinheim 2003, p. 178-186.


36. H. Gröger, E. Capan, A. Barthuber, K.-D. Vorlop
Biocatalytic Asymmetric Hydrocyanation in the Presence of (R)-Oxynitrilases Entrapped in Lens-Shaped Gels
Landbauforschung Völkenrode Sonderheft (Special Issue) 2002, 241, 87-91.
35. C. Schultz, H. Gröger, C. Dinkel, K. Drauz, H. Waldmann
Special Catalysts and Processes: Biocatalysis and Enzyme-Analogous Processes
Applied Homogeneous Catalysis with Organometallic Compounds (Eds.: B. Cornils, W. A. Herrmann), Volume 2, 2. ed., Wiley-VCH-Verlag, Weinheim 2002, p. 872-911


34. H. Gröger
The Development of New Monometallic Bifunctional Catalysts with Lewis Acid and Lewis Base Properties, and their Application in Asymmetric Cyanation Reactions
Chem. Eur. J. 2001, 7, 5246-5251.
33. H. Gröger
Enzymatic Routes to Enantiomerically Pure Aromatic α-Hydroxy Carboxylic Acids: A Further Example for the Diversity of Biocatalysis
Adv. Synth. Catal. 2001, 343, 547-558.
32. H. Gröger, E. Capan, A. Barthuber, K.-D. Vorlop
Asymmetric Synthesis of an (R)-Cyanohydrin Using Enzymes Entrapped in Lens-Shaped Gels
Org. Lett. 2001, 3, 1969-1972.
31. H. Gröger, J. Wilken
The Application of L-Proline as an Enzyme Mimic and Further New Asymmetric Syntheses Using Small Organic Molecules as Chiral Catalysts
Angew. Chem. 2001, 113, 545-548; Angew. Chem. Int. Ed. 2001, 40, 529-532.
30. G. Manickam, H. Nogami, M. Kanai, H. Gröger, M. Shibasaki
Anti- and Syn-Selective Cyanosilylation Reactions Promoted by a Sugar-Based Bifunctional Catalyst: Stereoselective Synthesis of Essential Building Blocks for HIV Protease Inhibitors and Bestatin
Synlett 2001, 617-620.


29. I. Schlemminger, Y. Saida, H. Gröger, W. Maison, N. Durot, H. Sasai, M. Shibasaki, J. Martens
Concept of Improved Rigidity: How to Make Enantioselective Hydrophosphonylation of Cyclic Imines Catalyzed by Chiral Heterobimetallic Lanthanoid Complexes Almost Perfect
J. Org. Chem. 2000, 65, 4818-4825.
28. H. Gröger, J. R. Goerlich, R. Schmutzler, J. Martens
The First Synthesis of a 2H-1,4-Benzothiazine-based Phosphine Oxide and Sulfide
Phosphorus, Sulfur, Silicon 2000, 166, 253-259.
27. H. Pennemann, S. Wassmann, J. Wilken, H. Gröger, S. Wallbaum, M. Kossenjans, D. Haase, W. Saak, S. Pohl, J. Martens
Preparation of an Enantiomerically Pure Helical Nickel(II) Complex Using a New Chiral Tetradentate Ligand Derived from an Industrial Waste Material
J. Chem. Soc., Dalton Trans. 2000, 2467-2470.
26. H. Gröger, J. Sans, T. Güthner
1,3,5-Triazines, versatile industrial building blocks: Synthetic approaches and applications
Chimica Oggi / Chemistry Today 2000, 18(3/4), 12-15.
25. H. Gröger
Moderne Methoden der Suzuki-Kreuzkupplung: Die langerwarteten universellen Synthesevarianten mit Arylchloriden
J. Prakt. Chem. 2000, 342, 334-339.
24. H. Gröger, B. Hammer
The Catalytic Concepts for the Enantioselective Synthesis of α-Amino and α-Hydroxy Phosphonates
Chem. Eur. J. 2000, 6, 943-948.


23. K.-i. Yamada, S. J. Harwood, H. Gröger, M. Shibasaki
The First Catalytic Asymmetric Nitro-Mannich-type Reaction Promoted by a New Heterobimetallic Complex
Angew. Chem. 1999, 111, 3713-3715; Angew. Chem. Int. Ed. 1999, 38, 3504-3506.
22. M. Shibasaki, H. Gröger
Chiral Heterobimetallic Lanthanoid Complexes: A Highly Efficient Multifunctional Catalyst for the Asymmetric Formation of C-C, C-O, and C-P Bonds
Topics in Organometallic Chemistry; Volume 2: Lanthanides: Chemistry and Use in Organic Synthesis, Ed.: S. Kobayashi, Springer-Verlag, Heidelberg 1999, p. 199-233.
21. M. Shibasaki, H. Gröger
The Asymmetric Nitroaldol Reaction: Addition of Nitroalkanes to Aldehydes in the Presence of Heterobimetallic Lanthanoid Catalysts
Comprehensive Asymmetric Catalysis, Volume 3, Eds.: E. Jacobsen, A. Pfaltz, H. Yamamoto, Springer-Verlag, Heidelberg 1999, p. 1075-1090.
20. E. M. Vogl, H. Gröger, M. Shibasaki
Towards Perfect Asymmetric Catalysis: Additives and Co-catalysts
Angew. Chem. 1999, 111, 1672-1680; Angew. Chem. Int. Ed. 1999, 38, 1570-1577.


19. H. Gröger, E. M. Vogl, M. Shibasaki
New Catalytic Concepts for the Asymmetric Aldol Reaction
Chem. Eur. J. 1998, 4, 1137-1141.
18. H. Gröger, Y. Saida, H. Sasai, K. Yamaguchi, J. Martens, M. Shibasaki
A New and Highly Efficient Route to Cyclic α-Amino Phosphonates: The First Catalytic Enantioselective Hydrophosphonylation of Cyclic Imines Catalyzed by Chiral Heterobimetallic Lanthanoid Complexes
J. Am. Chem. Soc. 1998, 120, 3089-3103.
17. H. Gröger, J. Wilken, J. Martens, I. Neda, R. Schmutzler
The First Synthesis of Cyclic α-Amino Phosphonic Acid Amides Bearing the Benzodiazaphosphorinanone System
Heteroatom Chem. 1998, 9, 679-686.


16. H. Gröger
Nukleophile Additionsreaktionen an die C=N-Doppelbindung schwefelhaltiger, cyclischer Imine unter Berücksichtigung stereoselektiver Aspekte
Dissertation 1997, University of Oldenburg.
15. H. Gröger, J. Martens, J. R. Goerlich, R. Schmutzler
A Novel Synthetic Approach to α-Aminophosphine Sulfide Structures: The First Dimethylphosphine Sulfide Addition to 3-Thiazolines
Phosphorus, Sulfur, Silicon 1997, 128, 153-163.
14. I. Reiners, H. Gröger, J. Martens
A New Enantioselective Synthetic Approach to β-Aminothio-compounds via Enantioselective Reduction of N,S-Heterocyclic Imines
J. Prakt. Chem. 1997, 339, 541-546.
13. J. Wilken, H. Gröger, M. Kossenjans, J. Martens
Synthesis and Application of New (threo)- and (erythro)-Amino Alcohols Based on the Octahydro-cyclopenta[b]pyrrol System in the Catalytic Enantioselective Addition of Diethylzinc to Benzaldehyde
Tetrahedron: Asymmetry 1997, 8, 2761-2771.
12. J. Wilken, C. Thorey, H. Gröger, D. Haase, W. Saak, S. Pohl, J. Muzart, J. Martens
Synthesis of New, Chiral β-sec-Amino Alcohols - Diastereodivergent Addition of Grignard-Reagents to α-Amino Aldehydes Based on the (all-R)-2-Azabicyclo-[3.3.0]octane-System
Liebigs Ann./Recueil 1997, 2133-2146.
11. J. Wilken, M. Kossenjans, H. Gröger, J. Martens
Synthesis and Application of New β-Amino Alcohols Based on the Octahydro-cyclopenta[b]pyrrol System in the Catalytic Enantioselective Addition of Diethylzinc to Benzaldehyde
Tetrahedron: Asymmetry 1997, 8, 2007-2015.
10. H. Gröger, D. Tehranfar, J. Martens, J. R. Goerlich, H. Thönnessen, P. G. Jones, R. Schmutzler
Synthesis of Dimethyl 4-Thiazolidinylphosphine Oxides via Addition of Dimethylphosphine Oxide to 3-Thiazolines
Heteroatom Chem. 1997, 8, 207-215.


9. H. Gröger, Y. Saida, S. Arai, J. Martens, H. Sasai, M. Shibasaki
First Catalytic Asymmetric Hydrophosphonylation of Cyclic Imines: Highly Efficient Enantioselective Approach to a 4-Thiazolidinylphosphonate via Chiral Titanium and Lanthanoid Catalysts
Tetrahedron Lett. 1996, 37, 9291-9292.
8. M. Hatam, J. R. Goerlich, R. Schmutzler, H. Gröger, J. Martens
The Totally Protected Hydroxy Containing α-Amino Phosphonic Esters and α-Amino Phosphinoxides as well as their Carbamoyl Derivatives
Synth. Commun. 1996, 26, 3685-3698.
7. I. Neda, T. Kaukorat, P. G. Jones, R. Schmutzler, H. Gröger, J. Martens
Chemistry of the 1,3,5-Triaza-2-phosphorine-4,6-diones, Part XI. Base-Catalyzed Addition Reactions of 2-Oxo-2-hydro-1,3,5-trimethyl-1,3,5-triaza-2λ4-phosphorine-4,6-dione to the C=N Double Bond of 3-Thiazoline Heterocycles
Z. Naturforsch. 1996, 51b, 1486-1493.
6. H. Gröger, J. Wilken, J. Martens, I. Neda, V. Pinchuk, H. Thönnessen, P. G. Jones, R. Schmutzler
Stereoselektive Pudovik-Reaktion von 5,6-Benzo-2H-1-methyl-3-(2‘-chlorethyl)-2-oxo-1,3,2λ4-diazaphosphorin-4-on mit einem 3-Thiazolin und MPL-Chromatographische Isolierung des Überschußdiastereomers
Z. Naturforsch. 1996, 51b, 1305-1312.
5. H. Gröger, J. Manikowski, J. Martens
Synthetic Approach to New α-Aminophosphonates Derived from Six-Membered, Sulfur-Containing Heterocyclic Imines
Phosphorus, Sulfur, Silicon 1996, 116, 123-132.
4. H. Gröger, M. Hatam, J. Kintscher, J. Martens
Synthesis of Glutathione Analogues, Peptide Nucleic Acids and Phosphono-oligopeptides from Heterocyclic Imines
Synth. Commun. 1996, 26, 3383-3394.
3. H. Gröger, J. Martens
Synthese Totalgeschützter Thioanaloga der 1,2,3,4-Tetrahydrochinolin-2-carbonsäure aus 2H-1,4-Benzothiazinen via Ugi-Reaktion
Sulfur Lett. 1996, 19, 197-206.
2. H. Gröger, J. Martens
Synthesis of New 4-Thiazolidinylphosphonates via Stereoselective Pudovik Reaction
Synth. Commun. 1996, 26, 1903-1911.


1. H. Gröger, M. Hatam, J. Martens
Synthese Totalgeschützter, Nichtproteinogener α-Aminosäuren und Oligopeptide aus 2H-1,3-Oxazinen und 2H-1,3-Benzoxazinen via Ugi-Reaktion
Tetrahedron 1995, 51, 7173-7180.