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| seit 12/2008 | PhD student in the group of Prof. Norbert Sewald at the University Bielefeld, Germany. Dissertation title “Synthese von Cryptophycin-Analoga für SAR- und subzelluläre Lokalisationsstudien” |
| 04/2008‑10/2008 | Diploma thesis in organic chemistry in the group of Prof. Dr. Frank Glorius at the Westfälische Wilhelms-Universität (WWU), Münster, Germany. Titel: “Ionenpaarkatalyse und asymmetrische Hydrierung-Entwicklung neuer Methoden” |
| 2003‑2008 | Studies in chemistry at the Westfälischen Wilhelms-Universität Münster, Germany |
| 06/2002 | Allgemeine Hochschulreife (Abitur), Gymnasium “St. Ursula” Dorsten, Germany |
| 10/2011 | “Insights for PhD Students”, BASF SE, Ludwigshafen, Germany |
| 06/2011 | 61st Meeting of Nobel Laureates, Lindau, Germany |
| 04‑10/2007 | Research internship in the group of Prof. G. C. Bazan at the University of California Santa Barbara (UCSB), California |
| 04/2007 | Stipend for a subject-based internship abroad, DAAD, German Academic Exchange Service |
Cryptophycins are a family of 16-membered cyclic depsipeptides produced as secondary metabolites by cyanobacteria. The retrosynthetic analysis of cryptophycin-1 leads to the four units A-D. Cryptophycin-1 and some artificial analogues proved to be extremely cytotoxic and cytostatic in biological screening studies. The bioactivity of cryptophycins is based on their ability to interact with tubulin. They display considerable cytotoxicity both against multidrug-resistant tumour cell lines and solid tumours. Cryptophycin-1 and cryptophycin-52 display an antitumour activity with 100 to 1000-fold increased potency compared to the chemotherapeutics paclitaxel and vinblastine. As a consequence, cryptophycin derivatives are considered as potential antitumour drugs. Cryptophycin-52 entered phase II clinical trials but failed due to its high neurotoxicity.
Modified cryptophycins were synthesised for structure-activity relationship studies and biochemical application. Fluorescent labelling of the cryptophycin moiety should allow qualitative and quantitative determinations of cellular events at molecular level.
Diethyl Tartrate (Review), C. Weiss, Synlett 2011, 1333-1334.
Synthesis and Application of a Chiral Diborate, Y. Loewer, C. Weiss, A. T. Biju, R. Fröhlich, F. Glorius, J. Org. Chem. 2011, 76, 2324-2327.
Approaches for the Synthesis of Functionalized Cryptophycins, B. Sammet, T. Bogner, M. Nahrwold, C. Weiss, N. Sewald, J. Org. Chem. 2010, 75, 6953-6960.
| 03/2011 | “Localization of a Cryptophycin Prodrug inside Cells”, 10th German Peptide Symposium, Berlin, Germany |
| 09/2010 | “Total Synthesis of Azide Functionalized Cryptophycins”, 31st European Peptide Symposium, Copenhagen, Denmark |
| 03/2010 | “Total Synthesis of Azide Functionalized Cryptophycins”, Frontiers in Medicinal Chemistry, Münster, Germany |
| 07/2009 | “Total Synthesis of Modified Cryptophycins”, 21st International Symposium: Synthesis in Organic Chemistry, Oxford, UK |
| 09/2011 | “Modified Cryptophycins – Synthesis of Novel Chemotherapeutics”, GDCh Wissenschaftsforum Chemie, Bremen, Germany |
Here you will find personal data and further information about the members of the workgroup Organic Chemistry III.
| Mrs. Iris Dopheide | |
| Room: | F2-139 |
| Phone: | 0521 106 6963 |
| Fax: | 0521 106 8094 |
| E-Mail: | sekretariat.oc3@uni-bielefeld.de |
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