Enzymatic Baeyer-Villiger oxidations with cyclohexanone monooxygenase (December 1999 to Deccember 2000).
Marina Vogel was born in Crimmitschau (Saxonia) in 1957 and studied chemistry at the University of Leipzig from 1976 to 1981. She worked as a scientific assistant at the Department of Chemistry of the University of Leipzig from 1981 to 1992. In 1985 she finished her PhD thesis in heterocyclic chemistry (“Synthesis of substituted and azolo-condensed quinoxalines“). In 1987 she worked in the group of Prof. P.B. Terentyev at the Lomonossov University in Moscov (“Biohydroxylation of substituted pyridines“). In 1994 she started her work for habilitation in the group of Prof. P. Welzel in Leipzig. She has one son who was born in 1992.
Monooxygenases like the cyclohexanone monooxygenase from Acinetobacter NCIMB 9871 which are able to catalyze both Baeyer-Villiger oxidations and the oxidation of heteroatoms are of special interest for organic synthesis. Up to now an application of these enzymes on larger scale has not been possible because of the cofactor dependency of all known Baeyer-Villiger enzymes and the problems of the production of large quantities of stabilized enzymes. We have developed a cheap and effective cofactor regeneration system (in co-operation with Prof. U. Kragl, University of Rostock, and Prof. V.I. Tishkov, Moscov State University) which is fundamentally for the realization of enzymatic Baeyer-Villiger oxidations in the chemical laboratory. Currently, the enantioselective sulfoxidation with cyclohexanone monooxygenase using the new cofactor regeneration system is also under investigation (in co-operation with Prof. U. Kragl, University of Rostock, and Prof. M.M. Kayser, University of New Brunswick, St. John, Canada). The production of the cyclohexanone monooxygenase as well as its modification by the application of modern methods of molecular biology and biochemistry and the investigation of substrate-enzyme interactions will be the topic of our work in the future.
Here you will find personal data and further information about the members of the workgroup Organic Chemistry III.
|Mrs. Iris Dopheide|
|Phone:||0521 106 6963|
|Fax:||0521 106 8094|