Fakultät für Chemie - Team
 
 
Hintergrundbild
Hintergrundbild
 deutsch
Uni von A-Z
  
Bielefeld University > Department of Chemistry > Organic Chemistry III > Team

Personal data for Dr. Tobias Bogner

  Dr. Tobias Bogner
Dr. Tobias Bogner
wiss. Mitarbeiter
Room: F2-240
Phone: 0521 106 2144
E-Mail:

Research


The cryptophycins are a family of macrocyclic depsipeptides produced as secondary metabolites by cyanobacteria of the genus Nostoc. The cryptophycins bind to tubulin which results in disturbance of microtubule dynamics. Hence, cryptophycins display a very high level of cytotoxicity even against multi drug-resistant tumor cell lines. That is why cryptophycin-52 was investigated as a cytostatic drug in clinical phase II studies. However, the studies failed due to dose-limiting neurotoxicity. Structure activity relationship (SAR) studies are performed by us to find cryptophycins with lower toxicity.


The cytotoxicity of cryptophycin-52 and its analogues are determined in cell-based cytotoxicity assays using both the non-multidrug-resistant cell line KB-3-1 and the multidrug-resistant cell line KB-V1 expressing P-glycoprotein (P-gp). The assay is based on the reduction of resazurin to fluorescent resorufin by living cells. The amount of fluorescence is proportional to the number of living cells.


Personal Data

Here you will find personal data and further information about the members of the workgroup Organic Chemistry III.

Secretariat

Mrs. Iris Dopheide
Room:F2-139
Phone:0521 106 6963
Fax:0521 106 8094
E-Mail:sekretariat.oc3@uni-bielefeld.de