Model studies on the function of acidic matrix proteins in biomineralisation

The biological processes leading to the observed structural diversity of biominerals are still widely unrevealed. Following the presently favoured template-matrix-hypothesis, the organic matrix of calcium-containing biominerals (e.g. bones, molluscular shells) contains specific macromolecules which stimulate or inhibit the in situ crystal seed formation and determine the orientation of the crystal growth. Since comprehensive information on the structure of the natural matrix macromolecules is presently not available yet, synthetic model molecules are being developed, which will emulate in suitable model systems all decisive aspects of the assumed structure and function of the natural systems.

Acidic Peptides Acting as Growth Modifiers of Calcite Crystals
D. Volkmer, M. Fricke, T. Huber, N. Sewald
J. Chem. Soc., Chem. Commun., 2004, 1872-1873.

People involved:
Dr. Thomas Huber

Prof. Dr. Dirk Volkmer, Ulm


Here you find Information about the projects of the workgroup Organic Chemistry III.