Date: 30 September - 2 October 2019
Convenors: Jens Stoye (Bielefeld, GER), Alexander Schönhuth (Amsterdam, NED)
The pan-genome of a species is defined as the entire genomic repertoire of its individuals, capturing naturally occurring local polymorphisms and structural variations. Recent technological developments have made it possible to get a good estimate of a pan-genome by massive sequencing. On the one hand, this allows to gain insight into the community structures of a species, their commonalities and their differences in detail. This is of particular importance as such community studies generally exhibit some significant diversity among (subgroups of) individuals as well as dynamics among different points in time and under different conditions. On the other hand, for the analysis of an individual genome, a pan-genome offers a much more robust and informative reference than the traditional single reference genome.
In this workshop, experts in computational biology and bioinformatics will discuss efficient representations of pan-genomes, algorithms for their analysis and various practical applications, integrating mathematical aspects (graph theory, statistics), computer science (data structures, algorithms), and biological/medical questions.