Vacant PhD Postitions

RNA interactome capture in plants

We are currently offering a PhD position in ribonomics based on CRISPR technology.

This project aims to develop a method to isolate RNA-binding proteins bound to a specific circadian transcript by in vivo UV cross-linking of RNA-protein complexes, RNA pull-down via specific antisense oligonucleotides and identification of bound proteins by mass spectrometry. The project will identify novel RBPs regulating circadian stress-responsive transcripts and shed light on this largely unexplored layer of post-transcriptional gene regulation.

More information is available here.

Applications including CV, research interest and contact information of references (single pdf) should please be sent to:
Prof. Dr. Dorothee Staiger (dorothee.staiger@uni-bielefeld.de).

Micro(RNA)managing – A CRISPR-based RNA-affinity approach

The DFG-funded project aims at analyzing ribonucleoprotein complexes involved in the regulation of miRNA biogenesis using ribonomics approaches in plants. We will exploit a CRISPR-based system to identify RNA-binding proteins directly binding to transcripts and their physiological relevance will be analyzed. To obtain further insights into the molecular mechanism of RBP action, genome-wide RBP binding sites will be identified. Overall, this will deliver new insight into molecular mechanisms underlying posttranscriptional regulation by plant RBPs and will advance our understanding of regulatory principles of eukaryotic gene expression.

More information is available here.

Applications including CV, research interest and contact information of references (single pdf) should please be sent to:
Dr. Tino Köster (tino.koester@uni-bielefeld.de).

Vacant Postitions

Postdoc position in RNA-based regulation of gene expression

We are currently offering a PostDoc position in RNA-based regulation using state-of-the-art methods to unravel posttranscriptional networks.

  • What are we looking for?
    Motivated candidates for projects to unravel molecular mechanisms of RNA-based regulation

  • What do we offer?
    The possibility to work in an international team; state-of-the-art methods to unravel posttranscriptional networks (RNA-seq, iCLIP, RNA affinity purification); modern lab infrastructure; participation in a doctoral degree program; the possibility for scientific exchange within the University; and possibilities for research stays abroad in the labs of international collaboration partners.

  • What do you bring in?
    PhD in biochemistry, genetics or similar research areas; expertise in RNA biology and protein biochemistry; basic knowledge in bioinformatics; willingness to apply for third party funding; creativity and teamwork abilities.

The position is limited to three years initially. Applications from suitably qualified handicapped persons are explicitly encouraged. The University welcomes applications from women.

Applications including CV, research interest and contact information of references (single pdf) should please be sent to dorothee.staiger@uni-bielefeld.de.

For informal enquiries please contact Prof. Dr. Dorothee Staiger