We aim to design, evolve, understand and apply enzymes for new catalytic reactions.
Our research group combines methods from organic chemistry, protein biochemistry and directed evolution to design, apply and understand new enzyme function. Completely new catalytic reactions can be envisioned in enzymes, because their macromolecular structure enables a very high level of molecular recognition to control catalytic cycles. Reaction discovery and development in enzyme active sites benefit from the ability to precisely bind substrates in defined conformations, to guide competing reactions pathways and to control highly reactive intermediates such as carbocations and radicals.
We aim to develop a new class of catalysts for synthetic organic chemistry that is protein-based, fully genetically encoded and catalyzes fundamental C-C, C-N and C-O bond formations that do not have a good catalytic solution. These new enzymes will potentially be applied in organic synthesis, increase our understanding in enzymology and can expand the metabolism in living organisms.
Hammer SC, Knight AM, Arnold FH. Curr. Opin. Green Sustain. Chem. 2017, 7, 23. One of the most cited articles in Current Opinion in Green and Sustainable Chemistry.
Hammer SC, Marjanovic A, Dominicus JM, Nestl BM, Hauer B. Nat. Chem. Biol. 2015, 11.
Chemical Laboratory Assistant
Alina is our Bielefeld local and manages our lab. She joined the group after successfully completing her training as chemical laboratory assistant at Bielefeld University.
Kai is from southern Germany, studied technical biochemistry at Stuttgart University and already made an internship in industry (Roche Biocatalysis). He joined us with a DBU PhD scholarship.