Our research group combines methods from organic chemistry, enzymology and directed evolution to design, evolve, apply and understand new enzyme function. We aim to develop biocatalysts for synthetic organic chemistry catalyzing fundamental C-C, C-N and C-O bond formations that do not have a good catalytic solution. These new enzymes will be applied in synthesis, increase our understanding in enzymology and can expand the metabolism in living organisms.
Gergel S, Soler J, Klein A, Schülke K, Hauer B, Garcia-Borràs M, Hammer SC
Nature Catalysis, 2023, 6, 606-617
News & Views: E. O'Reilly and M. Haarr Nature Catalysis, 2023, 6, 561-562
Highlighted by B. List and M. Brunen in Synfacts 2023, 19, 1030
Gajdoš M, Wagner J, Ospina F, Köhler A, Engqvist MKM, Hammer SC
Angew. Chem. Int. Ed. 2023, 62, e202215093
Ospina F, Schülke KH, Soler J, Klein A, Prosenc B, Garcia-Borràs M, Hammer SC
Angew. Chem. Int. Ed. 2022, 61, e202213056
Selected as VIP paper by Angewandte Chemie
Highlighted by B. List and M. Turberg in Synfacts 2023, 19, 0080
Soler J, Gergel S, Klaus C, Hammer SC, Garcia-Borràs M
J. Am. Chem. Soc. 2022, 144, 15954-15968
Schülke KH, Ospina F, Hörnschemeyer K, Gergel S, Hammer SC
ChemBioChem, 2022, 23, e202100632.
Selected as VIP paper by ChemBioChem
Highlighted in the ChemBioTalents 2022/23 collection
Bengel LL, Aberle B, Egler-Kemmerer AN, Kienzle S, Hauer B, Hammer SC
Angew Chem Int Ed, 2021, 60, 5554-5560
Selected as VIP paper by Angewandte Chemie
Highlighted by B. List and J.L. Kennemur in Synfacts 2021, 17, 0322
Hammer SC, Kubik G, Watkins E, Huang S, Minges H, Arnold FH
Science 2017, 358, 215-218
Highlighted by S. Bormann in C&EN
Highlighted by B. List and G.A. Shevchenko in Synfacts 2018, 14, 0083
Highlighted by ACS in Chemistry Research of the year 2017
Doctoral Researcher
Lucas is French and he studied organic chemistry in Marseille (France) and Trondheim (Norway). Lucas worked with Dr. Hervé Clavier and completed his master thesis with Prof. Elisabeth Jacobsen.
Dr. Christoph Diehl
Postdoctoral Researcher
Chris studied microbiology and received his PhD with Prof. Tobias Erb (Marburg, DE) by combining synthetic metabolism and machine learning. Chris is also recipient of the 2023 Dissertation Award of Synthetic Biology.
Doctoral Researcher
Shubhanshu is from Madhya Pradesh (India) and studied chemistry at the Indian Institute of Technology (IIT) Bombay. Shubhanshu joined our group after his master thesis with Prof. Debabrata Maiti.
Doctoral Researcher
Cindy is from Switzerland where she studied chemical biology at ETH Zürich. Cindy joined us after her master thesis with Prof. Donald Hilvert.
Vanessa Reitz
Doctoral Researcher
Vanessa studied biology and biochemistry at the Philipps University of Marburg (Germany) and joined us after her master thesis with Dr. Johannes Rebelein at the Max Planck Institute of Terrestrial Microbiology.
Doctoral Researcher
Felipe comes from Colombia and is a chemist by training. Before joining our group, Felipe worked as lecturer and research assistant with Prof. Felipe Otálvaro at Universidad de Antioquia in Medellín.