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  • Allgemein- und Familienmedizin

    AG5 Allgemein- und Familienmedizin

Prof. Dr. med. Christiane Muth, MPH

Head of AG5 ‘Allgemein- und Familienmedizin’


Telephone: +49 521 106-67982

  • Clinical decision support in multimorbidity / polypharmacy in primary care
  • Clinical decision support in chronic heart failure
  • Methods' development with a focus on evidence-based clinical practice guidelines


  • 1993 Licence to practise medicine
  • 1999 Certified as specialist in internal medicine (‘Landesaerztekammer’ Westfalen-Lippe)
  • 2003 Master of Public Health
  • 2008 Doctoral Thesis
  • 2019 PhD Thesis (‘Habilitation’) in General Practice


  • 1982 – 1985 Medicine, University of Leipzig
  • 1986 – 1991 Medicine, Westphalian Wilhelm University, Muenster
  • 2000 – 2001 Postgraduate Public Health studies, Hanover Medical School (MHH) Clinical Practice

Clinical Practice:

  • 1991 – 1998 Internal residency at Minden Clinic, Westphalia (gastroenterology, cardiology and intensive care, haematology and oncology, nephrology and dialysis, rheumatology, endocrinology and physical therapy)
  • 1998 – 1999 Internal residencies at Hamelin District Hospital and at Rahden hospital, Westphalia
  • 1999 – 2000 Freelance work at a group practice

Research Activities:

  • 2001 – 2003 Researcher in the working group on Health Technology Assessment at the Institute for Epidemiology, Social Medicine and Health Systems Research, Hanover Medical School
  • 2004 – 2021 Institute of General Practice at the Schleswig-Holstein University, Campus Kiel and at the Goethe University, Frankfurt / Main, Director: Prof. Ferdinand M. Gerlach: Senior Researcher, Head of Clinical Decision Support Unit
  • Since 2008 Participant at the International Primary Care Research Leadership Programme at the University of Oxford (formerly ‘Brisbane Initiative’)
  • Since 2012 Founding member of the International Research Network on Multimorbidity ‘Threads and Yarns‘
  • Since 2017 Invited member of the Frankfurt Forum on Interdisciplinary Ageing Research (FFIA)
  • 2017 Visiting professor at the Centre for Research in Evidence-Based Practice (CREBP) at Bond University, Queensland, Australia after placements in 2011 and 2013 to collaborate with Prof. Paul Glasziou
  • University Professor of General Practice and Family Medicine, Head of AG5 ‘Allgemein- und Familienmedizin’, Medical School of East-Westphalia, University of Bielefeld
  • Dreischulte T, Shahid F, Muth C, Schmiedl S, Haefeli WE: Prescribing cascades: how to detect them, prevent them, and use them appropriately. Dtsch Arztebl Int 2022; 119: 745–52. DOI: 10.3238/arztebl.m2022.0306 Link
  • Dinh TS*, Brückle MS, González-González AI, Fessler J, Marschall U, Schubert-Zsilavesz M, Gerlach FM, Harder S, van den Akker M, Schubert I, Muth C. Evidence-based decision support for a structured care program on polypharmacy in multimorbidity: a guideline upgrade based on a realist synthesis. J Pers Med 2022, 12, 69. Link
  • González-González AI, Nguyen TS, Meid AD, Blom JW, van den Akker M, Elders PJM, Thiem U, Kuellenberg de Gaudry D, Snell K, Perera R, Swart KMA, Rudolf H, Bosch-Lenders D, Trampisch H-J, Meerpohl JJ, Flaig B, Kom G, Gerlach FM, Hafaeli WE, Glasziou PP, Muth C. Predicting negative health outcomes in older general practice patients with chronic illness: rationale and development of the PROPERmed harmonized individual participant data database. Mech Ageing Dev 2021;194:111436. doi: Link
  • Blom JW, Muth C, Glasziou PP, McCormack J, Perera R, Poortvliet R, Numans M, Thürmann P, Thiem U, Thio SL, van Driel M, Beyer M, van Den Akker M, Knottnerus JA. Describing deprescribing trials better: an elaboration of the CONSORT statement. J Clin Epidemiol 2020 doi: Link
  • Gonzalez AI, Schmucker C, Nothacker J, Motschall E, Nguyen TS, Brueckle M-S, Blom JW, van den Akker M, Röttger K, Wegwarth O, Hoffmann T, Straus SE, Gerlach FM, Meerpohl JJ, Muth C. Health-related preferences of older patients with multimorbidity: an evidence map. BMJ Open 2019;9:e034485. doi: Link
  • Muth C, Blom JW, Smith SM, Johnell K, Gonzalez-Gonzalez AI, Nguyen TS, Brueckle MS, Cesari M, Tinetti ME, Valderas JM. Evidence supporting the best clinical management of patients with multimorbidity and polypharmacy: a systematic guideline review and expert consensus. J Intern Med. 2019;285(3):272-88., First published: 24 October 2018; Link
  • Muth C, Uhlmann L, Haefeli WE, Rochon J, van den Akker M, Perera R, Güthlin C, Beyer M, Oswald F, Valderas JM, Knottnerus JA, Gerlach FM, Harder S. Effectiveness of a complex intervention on Prioritising Multimedication in Multimorbidity (PRIMUM) in primary care: results of a pragmatic cluster randomised controlled trial. BMJ Open 2018;8:e017740. doi: Link
  • Muth C, Harder S, Uhlmann L, Rochon J, Fullerton B, Güthlin C, Erler A, Beyer M, van den Akker M, Perera R, Knottnerus A, Valderas J, Gerlach FM, Haefeli WE. Pilot study to test the feasibility of a trial design and complex intervention on PRIoritising MUltimedication in Multimorbidity in general practices (PRIMUMpilot). BMJ Open 2016;6(7):e011613. doi: Link
  • Muth C, van den Akker M, Blom JW, Mallen CD, Rochon J, Schellevis FG, Becker A, Beyer M, Gensichen J, Kirchner H, Perera R, Prados-Torres A, Scherer M, Thiem U, van den Bussche H, Glasziou PP. The Ariadne principles: how to handle multimorbidity in primary care consultations. BMC Med 2014; 12:223.
  • Muth C, Kirchner H, van den Akker M, Scherer M, Glasziou PP. Current guidelines poorly address multimorbidity: pilot of the interaction matrix method. J Clin Epidemiol 2014;67(11):1242-50. doi: 10.1016/j.jclinepi.2014.07.004 Epub 2014 Sep 9
  • Muth C, Gensichen J, Beyer M, Hutchinson A, Gerlach FM. The Systematic Guideline Review: Method, Rationale, and Test on Chronic Heart Failure. BMC Health Services Research 2009;9:74. URL: Link ; Accessed 25/10/2013