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Cell Biology

Cardiac Stem Cells

Cardiovascular diseases are the leading cause of death worldwide and are closely linked to the aging process. As we age, adult stem cells in the heart lose their ability to proliferate and regenerate tissue, which diminishes the heart's overall regenerative capacity. This makes understanding and improving the regenerative potential of human cardiac stem cells (hCSCs) a key area of interest for treating these diseases.

Recent research has shown that human blood serum can significantly enhance the proliferation of hCSCs and reduce their senescence, or aging. This effect appears to be independent of the donor's age and sex, indicating a broad potential application for rejuvenating heart tissue. Studies have identified several signaling pathways involved in this process, including the transcription factor NF-κB and the TGFβ signaling pathway. These pathways help regulate cell proliferation and prevent excessive aging of the cells.

Application of human blood serum and human blood plasma on adult human cardiac stem cells led to increased cell proliferation. (A) Primary cultures of human stem cells from the adult heart auricle where exposed to blood serum, blood plasma or starvation medium. (B) Microscopy images of treated cells demonstrated a proliferation inducing effect of blood serum and plasma compared to untreated cells. (C) Serum and plasma significantly increased the proliferation of hCSCs in a similar manner. Mann-Whitney two-tailed, * p < 0.05 was considered significant, not significant (n.s.) p > 0.05 [1].

References

[1] Höving et al.: Blood Serum Stimulates p38-Mediated Proliferation and Changes in Global Gene Expression of Adult Human Cardiac Stem Cells. Cells. 2020.

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