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Cytotoxic dinuclear Cu₂ and Ni₂ Complexes

Campus der Universität Bielefeld
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Cytotoxic dinuclear Cu₂ and Ni₂ Complexes (collaboration with Thorsten Glaser and Dario Anselmetti)

A dinuclear Cu₂complex was designed and synthesized that targets two neighboring phosphates of DNA. We could demonstrate this complex binds DNA, blocks DNA synthesis in PCR reactions and is cytotoxic for human cancer cells (details). The dinuclear Ni₂ complex was also cytotoxic (details).

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