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  • Medizinische Fakul­tät OWL

    Grafik vom Gebäude R.1 der Medizinischen Fakultät OWL
    © Universität Bielefeld

Projects in the NUM with location participation

In the first funding phase (2020 to 2021) within the framework of the Netzwerk Universitätsmedizin (NUM), 13 research projects were designed, each involving a large number of German University Medical Centers. The location was already able to successfully participate in some research projects during the first funding period. In the second funding period, which starts in 2022, Bielefeld University, the Medical School and the University Medical Center OWL will also be involved in numerous projects in various constellations.


Here you will find brief descriptions and further information on the projects of the 1st and 2nd funding period in which the location OWL is involved.

NUM 1.0

DEFEAT PANDEMIcs

  • "German autopsy research network for pandemics"
  • Establishment of a Germany-wide autopsy network for the pandemic, in which data, biomaterials and findings are collected and brought together in a systematic and standardised manner. This unique network enables a deeper understanding of the disease and helps to develop more effective therapeutic approaches.
  • Project management at the location:
    • Prof Dr Torsten Hansen (formerly Hospital Lippe)

"National pandemic cohort network"

  • Establishment of a network to collect high quality clinical phenotyping data, including biospecimen and imaging data.
  • Further information: Project website
  • Project management at the location:
    • Prof. Dr Eckard Hamelmann
      Bielefeld University
      Medical School and University Medical Center OWL
      Protestant Hospital of the Bethel Foundation
      Department of Pediatrics
    • Prof. Dr Christoph Stellbrink
      Bielefeld University
      Medical School and University Medical Center OWL
      Hospital Bielefeld
      Department of Cardiology and Internal Intensive Care Medicine

    • Prof. Dr Johannes-Josef Tebbe
      University Medical Center OWL
      Hospital Lippe
      Department of Gastroenterology and Infectious Diseases

NUM 2.0

Research Line

  • "Action Alliance for Information and Communication Technology in Intensive Care and Emergency Medicine"

  • Expansion of the AKTIN emergency department register, which emerged from an earlier BMBF project, into a comprehensive infrastructure for real-time care research in emergency departments.

  • Connection of further emergency departments.

  • Further information: Project website

  • Project management at the location:

    • Dr Sebastian Gaus
      Bielefeld University
      Medical School and University Medical Center OWL
      Protestant Hospital of the Bethel Foundation
      University Hospital for Paediatrics and Adolescent Medicine

    • Prof. Dr Eckard Hamelmann
      Bielefeld University
      Medical School and University Medical Center OWL
      Protestant Hospital of the Bethel Foundation,
      University Clinic for Paediatrics and Adolescent Medicine

    • Dr Hans-Werner Kottkamp
      University Medical Center OWL,
      Protestant Hospital of the Bethel Foundation,
      Central Emergency Departments

    • Dr Kai Johanning
      University Medical Center OWL
      Hospital Bielefeld
      Clinic for Anaesthesiology, Surgical Intensive Care Medicine, Emergency Medicine and Pain Therapy

    • Prof. Dr. Markus Roessler
      University Medical Center OWL
      Hospital Bielefeld
      Clinic for Anaesthesiology, Surgical Intensive Care Medicine, Emergency Medicine and Pain Therapy

  • "Collaborative Data Exchange and Usage"
  • The CODEX platform was created in the first funding phase of NUM, which has since been transferred to the NUM routine data platform (RDP) infrastructure and expanded to include technical and organisational aspects.
  • The aim is to create a flexible, sustainable, expandable and easy-to-use infrastructure for treatment data
  • Project management at the location:
    • Prof. Dr Christoph Karlheim
      University Medical Center OWL
      Protestant Hospital of the Bethel Foundation
    • Prof. Dr Michael Siniatchkin (formerly Protestant Hospital of the Bethel Foundation)
    • Enrico Niestroj
      Bethel Foundation
    • Christian Philipps
      Bielefeld University
      Medical School OWL
      Service Centre Medical Data Science
  • "Child health in the pandemic"
  • Covid-19 research platform for children and adolescents
  • The aim is to establish an interdisciplinary research and monitoring platform to investigate the effects of the Covid-19 pandemic on the physical and mental health of children and adolescents
  • Establishment of a sustainable, multidisciplinary network to be able to answer child-specific research questions in the current and future pandemics and social crisis situations in a timely manner
  • Project management at the location:

    • Prof. Dr Eckard Hamelmann
      Bielefeld University
      Medical School and University Medical Center OWL
      Protestant Hospital of the Bethel Foundation
      University Clinic for Paediatrics and Adolescent Medicine

    • Prof. Dr Michael Siniatchkin (formerly Protestant Hospital of the Bethel Foundation,
      University Clinic for Child and Adolescent Psychiatry and Psychotherapy)
  • "Genomic Pathogen Surveillance and Translational Research plus"
  • GenSurv+ extends the GenSurv infrastructure by analysing bacterial pathogens, especially multidrug-resistant bacteria, using whole genome sequencing.
  • Focusing on carbapenemase-producing enterobacterales, it improves surveillance, enables outbreak control and strengthens pandemic preparedness. By integrating this data with epidemiological information, GenSurv+ promotes evidence-based healthcare decisions.
  • Project management at the location:
  • "Genomic Pathogen Surveillance and Translational Research plus"
  • GenSurv+ erweitert die GenSurv-Infrastruktur, indem es bakterielle Krankheitserreger, insbesondere multiresistente Bakterien, mithilfe der Ganzgenomsequenzierung analysiert.
  • Mit Fokus auf Carbapenemase-produzierende Enterobacterales verbessert es die Surveillance, ermöglicht die Ausbruchskontrolle und stärkt die Pandemiebereitschaft. Durch die Integration dieser Daten mit epidemiologischen Informationen fördert GenSurv+ evidenzbasierte Entscheidungen im Gesundheitswesen.
  • Projektleitungen am Standort:
  • "Kindergesundheit in der Pandemie"
  • Covid-19 Forschungsplattform für Kinder und Jugendliche
  • Ziel ist der Aufbau einer interdisziplinären Forschungs- und Monitoringplattform zur Untersuchung der Auswirkungen der Covid-19 Pandemie auf die körperliche und seelische Gesundheit von Kindern und Jugendlichen
  • Etablierung eines nachhaltigen, multidisziplinären Netzwerks um kinderspezifische Forschungsfragen in der aktuellen und in zukünftigen Pandemien und gesellschaftlichen Krisensituationen zeitnah beantworten zu können
  • Projektleitungen am Standort:

    • Prof. Dr. Eckard Hamelmann
      Universität Bielefeld
      Medizinische Fakultät und Universitätsklinikum OWL
      Evangelisches Klinikum Bethel
      Universitätsklinik für Kinder- und Jugendmedizin

    • Prof. Dr. Michael Siniatchkin
      Universität Bielefeld
      Medizinische Fakultät und Universitätsklinikum OWL
      Evangelisches Klinikum Bethel
      Universitätsklinik für Kinder- und Jugendpsychiatrie und Psychotherapie
  • "Molecular Surveillance and Infection Chain Tracing for Local Public Health Authorities"
  • Molecular Surveillance and Infection Chain Tracing for Local Public Health Authorities
  • The aim is the effective use of genomic surveillance by local public health authorities and the integration into the GenSurv infrastructure (sub-project of the infrastructure line)
  • Project management at the location:

 

  • "National Pandemic Cohort Network - Therapeutic Intervention Platform"

  • The aim is to establish an infrastructure for conducting complex clinical trials in Germany.

  • Conceptual integration of strengths of internationally successful study platforms and adaptation to the specific national context in terms of regulation, Data protection and existing competence centres and networks, as well as to the possibilities and platforms of the Network of University Medicine (NUM).

  • Project management at the location:
  • "National pandemic cohort network"
  • The aim is to establish a research network for clinical studies in order to promote nationwide cooperation between doctors and researchers.
  • The focus is on the collection of data and biosamples from a high-quality cohort of patients with Covid-19 for an in-depth mapping of the disease and to answer scientific and care-relevant questions
  • Further information: Project website
  • Project management at the location:
    • Prof. Dr Eckard Hamelmann
      Bielefeld University
      Medical School and University Medical Center OWL
      Protestant Hospital of the Bethel Foundation
      University Clinic for Paediatrics and Adolescent Medicine
    • Prof. Dr Christoph Stellbrink
      Bielefeld University
      Medical School and University Medical Center OWL
      University Clinic for Cardiology and Internal Intensive Care Medicine
    • Prof. Dr Johannes-Josef Tebbe
      University Medical Center OWL
      Hospital Lippe
      Clinic for Gastroenterology and Infectiology
  • "PREparedness and PAndemic REsponse in "Germany"
  • The aim is to develop a concept for a realisable, cooperative, adaptive and sustainable infrastructure for pandemic preparation and management.
  • The concept should enable coordinated, rapid and evidence-based actions and responses to threats to patient care and public health and ensure coordinated research in the event of a pandemic
  • Project management at the location:

 

  • "RAdiological COOperative Network for the Covid-19 pandemic" -COMBINE
  • This project will be the first use case of the RACOON infrastructure (see RACOON_BI)
  • The aim is to develop and implement a pipeline for the extraction of COVID-specific, predictive and prognostic quantitative imaging biomarkers (C-QIBs) to enable comprehensive phenotyping not only of the disease, but also of the patient, i.e. their physical condition and concomitant diseases.
  • Further information: Project website
  • Project management at the location:

  • "Randomised adaptive assessment of post COVID syndrome treatments_Reducing Inflammatory Activity in Patients with post COVID Syndrome"

  • The study is the first use case conducted with the support of the NAPKON-TIP structure.

Project management at the location:

Infrastructure Line

  • Operation of the AKTIN Infrastructure and the Emergency Department Data Registry (AKTIN stands for "Alliance to improve communication and information technology in intensive care and emergency medicine".)
  • The AKTIN Emergency Departments Register is a standardised electronic infrastructure with which data that is collected electronically during patient care in the emergency department is made available for health reporting, quality assurance and health services research.
  • Further information: Project website
  • Project management at the location:
    • Dr Sebastian Gaus
      Bielefeld University
      Medical School and University Medical Center OWL
      Protestant Hospital of the Bethel Foundation
      University Hospital for Paediatrics and Adolescent Medicine
    • Prof. Dr Eckard Hamelmann
      Bielefeld University
      Medical School and University Medical Center OWL
      Protestant Hospital of the Bethel Foundation,
      University Clinic for Paediatrics and Adolescent Medicine
    • Dr. Hans-Werner Kottkamp
      University Medical Center OWL,
      Protestant Hospital of the Bethel Foundation,
      Central Emergency Departments
    • Dr. Kai Johanning
      University Medical Center OWL
      Hospital Bielefeld
      Clinic for Anaesthesiology, Surgical Intensive Care Medicine, Emergency Medicine and Pain Therapy
    • Prof. Dr. Markus Roessler
      University Medical Center OWL
      Hospital Bielefeld
      Clinic for Anaesthesiology, Surgical Intensive Care Medicine, Emergency Medicine and Pain Therapy
  • "Data Integration Centre"
  • The infrastructure project of the DIZ will form the decentralised technical and organisational prerequisites for the cross-location use of data between patient care and medical research for many existing and future research projects across all NUM locations in the future.

  • In the development and networking phase (2018-2022) of the MII, a total of 30 DIZs were set up at university medical centre locations. As part of the NUM-DIZ project, nine additional DIZs are to be set up from 2023.

  • Project management at the location:
    • Christian Philipps
      Bielefeld University
      Medical School OWL
      Service Centre Medical Data Science
  • "Genomic Pathogen Surveillance and Translational Research"
  • The aim is to expand the cooperation between RKI and university SARS-CoV-2 sequencing activities initiated in B-FAST, NUM 1.0, and the effective use of the information in the public health service. This includes:
    • The provision and further development of tools and pipelines for the collection and processing of sequencing data
    • The provision of a data hub to collect and analyse raw sequencing data
    • The provision of phenotypic characterisation capabilities
    • The expansion and evaluation of targeted sampling strategies
    • Continuous adaptation and further development for additional pathogens
  • Further information: Project website
  • Project management at the location:
  • "Nationales Obduktions-Netzwerk"
  • The aim is to provide a service, expert and development platform for networked autopsy-driven research
  • Projektleitung am Standort:
    • Dr. Birte Schulz
      University Medical Center OWL
      Hospital Lippe
      Institute of Pathology
  • "RAdiological COOperative Network for the Covid-19 pandemic" - basic infrastructure
  • Nationwide infrastructure for the collection of radiological data on Covid-19 cases
  • Further information: Project website
  • Project management at the location:
  • "Study network of the Network of University Medicine with integrated Specialised Network for Infection Medicine (NSN)"
  • The NUM Study Network (NSN) aims to develop an effective system of cooperation in the field of clinical and clinical-epidemiological studies in Germany. This involves close co-operation with existing infrastructures, networks and researchers.
  • The aim is to relieve study managers of administrative and operational tasks by consistently simplifying them and transferring them to study-supporting structures. As a result, more studies can be initiated in less time, more patients can be recruited for studies in a reliable period of time and the quality of data and biosample collection can be improved.
  • Further information: Project website
  • Project management at the location:
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