Health burdens and care requirements of certain population groups, e.g. women affected by violence, women and men with chronic illnesses and disabilities, as well as the question of health resources, mark an important focus of the work content both in teaching and research.
Based on a deep understanding of social interaction and human cognition, we develop effective intelligent assistance systems with the flexibility to co-construct interaction with different user groups.
The focus of our research group is on how microglia, as resident immune cells of the central nervous system (CNS), influence the development, functional maturation, physiological functions and the emergence and progression of brain diseases.
Die AG 4 Digitale Medizin befasst sich mit der Digitalen Transformation als einem fortlaufenden, in digitalen Technologien begründeten Veränderungsprozess, der das Gesundheitssystem, die beteiligten Kliniken, Universitäten und Professionen verändert. Sie bietet eine große Chance für eine bessere Gesundheitsversorgung. Dies setzt jedoch sowohl die Entwicklung und Evaluation digitaler Technologien, die Schaffung innovativer, digital unterstützter Behandlungsabläufe in Praxis und Klinik als auch die adäquate Qualifizierung der beteiligten Menschen voraus.
The research group General and Family Medicine focuses on people with chronic multiple illnesses and frequent multi-medication. These people often have intensive care needs and are particularly at risk from acute illnesses. The research group conducts research to improve their care and integrates relevant content into general medical education and training.
The department for Biochemistry and Molecular Medicine conducts research into rare inheritable brain and muscle diseases caused by defective formation and function of cell organelles. We are also investigating a novel gene regulatory mechanism based on translational readthrough (stop codon suppression). We are employing methods and techniques from biochemistry (proteins, lipids, in vitro systems), cell biology (iPSC, CRISPR/Cas, advanced microscopy), and cell and animal models.
Our research group is active in the areas of lifelong learning and medical decision making. We conduct progress tests of our medical students and help them identify strengths and weaknesses in their medical/clinical learning. We also research the evolution of medical decision making and seek to optimize its integration into the medical curriculum.
The research focus of our working group is in the area of excitation disorders of nerve and muscle cells, which are caused by altered membrane proteins (ion channels and receptors) and can, for example, cause mental illnesses or cardiac arrhythmias. The teaching content covers the areas of physiology and pathophysiology.
Lipid membranes form barriers, gateways, specialized compartments and microenvironments to permit physiological cellular functions. Our research focuses on the role of sphingolipids, membrane transporters and receptors in carcinogenesis and the development of oncogenic multidrug resistance.
Different persons can be affected differently by diseases. This can be attributed to biological causes (sex-related factors) as well as to different behavioral patterns or different access to medical care (gender-related factors). The work group is dedicated to sex- and gender-sensitive medicine and we support future doctors in the person-centered communication, diagnosis and therapy of all patients.
Our interdisciplinary group deals with the perception of light. We analyze the structure and function of receptors, which among others govern the daily rhythm and are applied in optogenetics. We develop infrared spectroscopy in aqueous media as a diagnostic tool for living cells and human cell lines.
The working group biostatistics and medical biometry generally deals with statistical theories and methods for describing, analysing and interpreting data and questions from life sciences and medical research. Our focus is on the development of statistical methods for meta-analyses and survival time analyses, as well as on the modelling of disease dynamics.
Translational pharmacology pursues research at the interface of non-clinical and clinical sciences. Our scientific focus is the personalization of drug therapy for chronic diseases. We investigate mechanisms of variability in therapeutic and adverse drug effects using laboratory experiments and carefully conducted proof-of-concept clinical studies.
In the University Hospital of Anaesthesiology, Intensive Care, Emergency Medicine, Transfusion Medicine and Pain Therapy, clinical care is provided across the entire spectrum of the listed disciplines. In addition, specialist training for professional development is offered and authorisized in respect to all these medical disciplines.
Focus of Research:
With a wide range of treatments and excellent performances in diagnosis and therapy of all kinds of acute and chronic diseases in children and adolescents, our University Hospital is a reliable partner for children, adolescents and their parents. In total, we attend 40.000 patients yearly, treating them as in- and outpatients or in our emergency unit.
As a research department of the University Clinic for Child and Adolescent Psychiatry and Psychotherapy, we study the development, treatment and prevention of mental disorders in childhood and adolescence. Within our department we are divided into two working groups with different focuses: the Working Group Clinical Psychology and the Working Group Clinical Neuropsychology.
Christian G. Bien
The Department of Epileptology offers the entire spectrum of diagnostics and treatment of seizure disorders. From a research standpoint, epilepsy is a window to the brain. Research-wise, we are concerned with, among other things, structural causes of epilepsy, autoimmune encephalitides and epilepsies, pharmacotherapy, epilepsy and disability or the social consequences of the disease. We use the opportunities of pre-surgical epilepsy diagnostics to gain insights into brain functions through neuropsychological and neurophysiological examinations. The focus here is on memory research.
At the University Hospital for Psychiatry and Psychotherapy, almost all mental disorders are treated in multiprofessional specialized areas on an outpatient, day-care and inpatient basis. The team at the University Hospital for Psychiatry and Psychotherapy serves the entire city of Bielefeld as an epidemiologic catchment area and is closely networked with the providers of community psychiatric and psychosocial services, addiction and elderly care in the region. We are also a member of the Academy of Psychiatry and Psychotherapy OWL (training of specialists and training of psychological psychotherapists in our own institute).
At the University Hospital for Trauma Surgery and Orthopedics at the Campus Bielefeld-Bethel, we treat all injuries to the bone and musculoskeletal system. As a supraregional trauma center of the highest care level, we ensure the care of severely injured patients in the region in close cooperation with other specialist disciplines. In addition, the University Hospital has been appointed by the German Statutory Accident Insurance for the treatment of severely injured patients after accidents at work. Thus, the clinic covers the entire spectrum of acute and elective musculoskeletal medicine.
The scientific focus is on the optimization of impaired bone healing, the specifics of the care of musculoskeletal pathologies in people with disabilities, the evaluation of innovative visualization techniques for therapy planning and rehabilitation, and intersectoral networking.
The research focus of our group is on cell biology, genetics and therapy of head and neck tumors as well as on inflammatory mechanisms in the middle ear and paranasal sinuses and on hearing physiology (cochlear implants). Our WG conducts research on the improved care of patients with head and neck tumors and chronic inflammation in the ENT area (chronic otitis media, cholesteatoma, chronic rhinosinusitis) and integrates relevant content into ENT education and training.
At the University Clinic of Cardiology, Angiology, and Intensive Care Medicine at Klinikum Lippe Detmold, Germany, we treat all cardiologic and angiologic emergencies within the Lippe region and offer personalized high-end therapies like complex and high-risk coronary interventions (CHIP), robotic PCI, transsectoral heart failure therapy, interdisciplinary angiology, and internal intensive care medicine. Another focus of our scientific activities is preventive cardiology including personalized prevention counselling and lipid management.
The University Institute of Laboratory Medicine, Microbiology and Clinical Pathobiochemistry provides the Lippe Hospital with its locations in Detmold and Lemgo, as well as outpatients and inpatients with a broad spectrum of laboratory medical and microbiological diagnostics and performs teaching and research tasks. The focus of research is "Precise Clinical Decision Support and Digital Laboratory Medicine", "Systems Medicine, Precise Spectroscopic Multiparameter Diagnostics", "Inflammation and Degeneration" and "Biomarker-Driven Precise Prevention". To this end, the laboratory and the diagnostic spectrum are being consistently further developed and a new building is planned at the Detmold Location. The institute supervises the Lippe biobank site and will actively accompany the establishment and phenotyping of large cohort studies with laboratory expertise.
The Department of Diagnostic and Interventional Radiology is the academic center for imaging diagnostics and image-guided therapy in OWL, providing the region with the whole spectrum of clinical radiology while at the same time working on new methods for medical image acquisition and analysis.
In collaboration with other diagnostic disciplines, we are working on concepts for integrated diagnoctics, combining information from imaging, medical chemistry and pathology to form multiparametric biomarker patterns for advances staging and monitoring of complex disease.
At the laboratory for preclinical imaging, located centrally at the university campus, experimental methodology allows for visualization of molecular and cellular processes in living organisms, enabling basic research in understanding of disease development and spread.